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Table 4 Pulmonary mRNA expression levels in mice, 1, 3 and 28 days post-exposure to 54 μg, 162 μg and 486 μg sanding dust from epoxy and 162 μg CB

From: Epoxy composite dusts with and without carbon nanotubes cause similar pulmonary responses, but differences in liver histology in mice following pulmonary deposition

  Control EPOXY-REF EPOXY-CNT EPOCYL CB
1 day 0 μg 54 μg 162 μg 486 μg 54 μg 162 μg 486 μg 54 μg 162 μg 486 μg 162 μg
 Il-6 0.08 ± 0.02 0.31 ± 0.19 1.19 ± 0.31*** 2.33 ± 0.53*** 1.45 ± 0.87** 2.32 ± 0.97*** 1.91 ± 0.50*** 0.26 ± 0.10* 2.43 ± 0.09*** 1.35 ± 0.35*** 0.21 ± 0.07
 Hmox-1 5.26 ± 0.62 5.98 ± 1.5 13.8 ± 3.0 19.2 ± 2.7** 25.6 ± 10.2 28.9 ± 4.9** 17.2 ± 2.6* 6.85 ± 1.7 17.6 ± 3.8 15.6 ± 3.4 6.22 ± 0.89
3 days            
 Il-6 0.07 ± 0.01 0.11 ± 0.03 0.51 ± 0.11** 0.6 ± 0.18*** 0.11 ± 0.03 0.33 ± 0.15 0.90 ± 0.30 0.14 ± 0.07 0.25 ± 0.07 4.00 ± 1.28*** 0.29 ± 0.11
 Hmox-1 3.95 ± 0.72 4.07 ± 0.75 5.28 ± 1.3 6.47 ± 1.7 5.41 ± 1.5 9.11 ± 2.5 14.2 ± 5.7 7.32 ± 2.2 7.74 ± 2.6 28.3 ± 7.7 5.84 ± 1.45
28 days            
 Il-6 0.24 ± 0.05 0.13 ± 0.03 0.21 ± 0.10 0.25 ± 0.08 0.15 ± 0.08 0.14 ± 0.05 0.17 ± 0.07 0.15 ± 0.03 0.11 ± 0.03 0.33 ± 0.11 0.21 ± 0.05
 Hmox-1 4.95 ± 0.72 5.46 ± 1.3 9.33 ± 2.0 7.72 ± 1.3 3.40 ± 0.84 7.00 ± 2.3 7.38 ± 2.5 6.63 ± 1.0 5.70 ± 0.40 12.9 ± 1.04 4.87 ± 1.6
  1. Normalised mRNA expression level of Il-6 and Hmox-1 (Mean ± SEM)
  2. There were no statistically significant differences between the three sanding dusts at the 0.05 level
  3. *p < 0.05 compared to controls, **p < 0.01 compared to controls, ***p < 0.001 compared to controls