Epoxy composite dusts with and without carbon nanotubes cause similar pulmonary responses, but differences in liver histology in mice following pulmonary deposition

Table 4 Pulmonary mRNA expression levels in mice, 1, 3 and 28 days post-exposure to 54 μg, 162 μg and 486 μg sanding dust from epoxy and 162 μg CB

	Control	EPOXY-REF			EPOXY-CNT			EPOCYL			CB
1 day	0 μg	54 μg	162 μg	486 μg	54 μg	162 μg	486 μg	54 μg	162 μg	486 μg	162 μg
Il-6	0.08 ± 0.02	0.31 ± 0.19	1.19 ± 0.31***	2.33 ± 0.53***	1.45 ± 0.87**	2.32 ± 0.97***	1.91 ± 0.50***	0.26 ± 0.10*	2.43 ± 0.09***	1.35 ± 0.35***	0.21 ± 0.07
Hmox-1	5.26 ± 0.62	5.98 ± 1.5	13.8 ± 3.0	19.2 ± 2.7**	25.6 ± 10.2	28.9 ± 4.9**	17.2 ± 2.6*	6.85 ± 1.7	17.6 ± 3.8	15.6 ± 3.4	6.22 ± 0.89
3 days
Il-6	0.07 ± 0.01	0.11 ± 0.03	0.51 ± 0.11**	0.6 ± 0.18***	0.11 ± 0.03	0.33 ± 0.15	0.90 ± 0.30	0.14 ± 0.07	0.25 ± 0.07	4.00 ± 1.28***	0.29 ± 0.11
Hmox-1	3.95 ± 0.72	4.07 ± 0.75	5.28 ± 1.3	6.47 ± 1.7	5.41 ± 1.5	9.11 ± 2.5	14.2 ± 5.7	7.32 ± 2.2	7.74 ± 2.6	28.3 ± 7.7	5.84 ± 1.45
28 days
Il-6	0.24 ± 0.05	0.13 ± 0.03	0.21 ± 0.10	0.25 ± 0.08	0.15 ± 0.08	0.14 ± 0.05	0.17 ± 0.07	0.15 ± 0.03	0.11 ± 0.03	0.33 ± 0.11	0.21 ± 0.05
Hmox-1	4.95 ± 0.72	5.46 ± 1.3	9.33 ± 2.0	7.72 ± 1.3	3.40 ± 0.84	7.00 ± 2.3	7.38 ± 2.5	6.63 ± 1.0	5.70 ± 0.40	12.9 ± 1.04	4.87 ± 1.6

Normalised mRNA expression level of Il-6 and Hmox-1 (Mean ± SEM)
There were no statistically significant differences between the three sanding dusts at the 0.05 level
*p < 0.05 compared to controls, **p < 0.01 compared to controls, ***p < 0.001 compared to controls

ISSN: 1743-8977