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Table 5 DNA damage (%T DNA) in lung and liver tissue, 1, 3 and 28 days post-exposure to 54 μg, 162 μg and 486 μg sanding dust from epoxy, 162 μg Printex 90 and control mice

From: Epoxy composite dusts with and without carbon nanotubes cause similar pulmonary responses, but differences in liver histology in mice following pulmonary deposition

  Control   EPOXY-REF    EPOXY-CNT    EPOCYL   CB
1 day 0 μg 54 μg 162 μg 486 μg 54 μg 162 μg 486 μg 54 μg 162 μg 486 μg 162 μg
 Lung 3.25 ± 0.32 3.79 ± 0.30 4.95 ± 0.70* 4.89 ± 0.71* 4.37 ± 0.25 5.80 ± 0.74 4.78 ± 0.42 5.53 ± 0.38* 5.67 ± 0.43* 5.20 ± 0.46 4.60 ± 1.29
 Liver 3.13 ± 0.47 3.90 ± 0.48 4.02 ± 0.55 3.30 ± 0.36 3.97 ± 0.71 3.08 ± 0.36 3.32 ± 0.48 3.47 ± 0.34 3.43 ± 0.23 3.07 ± 0.21 3.30 ± 0.24
3 days            
 Lung 4.28 ± 0.35 4.33 ± 0.36 4.88 ± 0.81 4.45 ± 0.72 5.02 ± 0.74 3.89 ± 0.30 4.30 ± 0.45 4.78 ± 0.54 8.08 ± 1.19** 8.38 ± 2.15* 4.75 ± 0.61
 Liver 3.29 ± 0.29 3.3 ± 0.36 3.22 ± 0.44 3.8 ± 0.38 3.25 ± 0.28 2.72 ± 0.24 3.52 ± 0.23 3.07 ± 0.21 3.4 ± 0.23 3.32 ± 0.24 3.62 ± 0.40
28 days           
 Lung 4.71 ± 0.98 3.13 ± 0.31 4.28 ± 0.49 4.83 ± 0.25 3.70 ± 0.30 3.90 ± 0.45 5.72 ± 0.74 5.28 ± 0.93 4.40 ± 0.65 7.28 ± 1.92 4.67 ± 0.73
 Liver 3.78 ± 0.34 3.37 ± 0.35 3.33 ± 0.17 2.78 ± 0.21 2.85 ± 0.27 3.38 ± 0.24 3.17 ± 0.25 3.43 ± 0.41 3.32 ± 0.36 3.63 ± 0.39 3.67 ± 0.55
  1. Mean ± SEM
  2. There were no statistically significant differences in response between the three epoxy dusts
  3. *p < 0.05 compared to controls,**p < 0.01 compared to controls