Skip to main content

Table 5 DNA damage (%T DNA) in lung and liver tissue, 1, 3 and 28 days post-exposure to 54 μg, 162 μg and 486 μg sanding dust from epoxy, 162 μg Printex 90 and control mice

From: Epoxy composite dusts with and without carbon nanotubes cause similar pulmonary responses, but differences in liver histology in mice following pulmonary deposition

 

Control

 

EPOXY-REF

  

EPOXY-CNT

  

EPOCYL

 

CB

1 day

0 μg

54 μg

162 μg

486 μg

54 μg

162 μg

486 μg

54 μg

162 μg

486 μg

162 μg

 Lung

3.25 ± 0.32

3.79 ± 0.30

4.95 ± 0.70*

4.89 ± 0.71*

4.37 ± 0.25

5.80 ± 0.74

4.78 ± 0.42

5.53 ± 0.38*

5.67 ± 0.43*

5.20 ± 0.46

4.60 ± 1.29

 Liver

3.13 ± 0.47

3.90 ± 0.48

4.02 ± 0.55

3.30 ± 0.36

3.97 ± 0.71

3.08 ± 0.36

3.32 ± 0.48

3.47 ± 0.34

3.43 ± 0.23

3.07 ± 0.21

3.30 ± 0.24

3 days

           

 Lung

4.28 ± 0.35

4.33 ± 0.36

4.88 ± 0.81

4.45 ± 0.72

5.02 ± 0.74

3.89 ± 0.30

4.30 ± 0.45

4.78 ± 0.54

8.08 ± 1.19**

8.38 ± 2.15*

4.75 ± 0.61

 Liver

3.29 ± 0.29

3.3 ± 0.36

3.22 ± 0.44

3.8 ± 0.38

3.25 ± 0.28

2.72 ± 0.24

3.52 ± 0.23

3.07 ± 0.21

3.4 ± 0.23

3.32 ± 0.24

3.62 ± 0.40

28 days

          

 Lung

4.71 ± 0.98

3.13 ± 0.31

4.28 ± 0.49

4.83 ± 0.25

3.70 ± 0.30

3.90 ± 0.45

5.72 ± 0.74

5.28 ± 0.93

4.40 ± 0.65

7.28 ± 1.92

4.67 ± 0.73

 Liver

3.78 ± 0.34

3.37 ± 0.35

3.33 ± 0.17

2.78 ± 0.21

2.85 ± 0.27

3.38 ± 0.24

3.17 ± 0.25

3.43 ± 0.41

3.32 ± 0.36

3.63 ± 0.39

3.67 ± 0.55

  1. Mean ± SEM
  2. There were no statistically significant differences in response between the three epoxy dusts
  3. *p < 0.05 compared to controls,**p < 0.01 compared to controls