Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 6 Type and incidence of histological lesions in the liver on days 1, 3 and 28 following exposure of mice to CNT, EPOXY-REF, EPOXY-CNT, EPOCYL or CB

From: Epoxy composite dusts with and without carbon nanotubes cause similar pulmonary responses, but differences in liver histology in mice following pulmonary deposition

Lesion Control CNT (μg/animal) EPOXY-REF (μg/animal) EPOXY-CNT (μg/animal) EPOCYL (μg/animal) CB (μg/animal)
0 18 54 162 54 162 486 54 162 486 54 162 486 162
Foci (small) of inflammatory cells
 Day 1 0/12 0/6 0/5 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6
 Day 3 0/22 1/6 0/6 2/5 0/6 0/6 0/6 0/6 1/6 1/6 0/6 2/6 1/6 0/6
 Day 28 0/24 2/6 1/6 1/6 0/6 0/6 0/6 1/6 2/6 2/6 1/6 2/6 2/6 0/6
Granuloma
 Day 1 0/12 0/6 0/5 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6
 Day 3 0/22 0/6 1/6 1/5 0/6 0/6 0/6 0/6 0/6 1/6 0/6 2/6 2/6 0/6
 Day 28 0/24 2/6 2/6 1/6 0/6 0/6 0/6 0/6 1/6 1/6 1/6 1/6 2/6 0/6
Polymorphonuclear cell foci
 Day 1 0/12 0/6 0/5 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6
 Day 3 0/22 0/6 1/6 1/5 0/6 0/6 0/6 0/6 0/6 1/6 0/6 1/6 1/6 1/6
 Day 28 0/24 2/6 1/6 3/6 0/6 0/6 0/6 1/6 1/6 0/6 1/6 1/6 2/6 2/6
Macrophages
 Day 1 0/12 2/6 1/5 1/6 0/6 0/6 0/6 1/6 0/6 0/6 0/6 1/6 0/6 0/6
 Day 3 0/22 1/6 2/6 1/5 0/6 0/6 0/6 1/6 2/6 2/6 1/6 2/6 2/6 0/6
 Day 28 0/24 1/6 2/6 2/6 0/6 0/6 0/6 0/6 2/6 2/6 1/6 1/6 1/6 0/6
Hyperplasia of connective tissue perivascular
 Day 1 0/12 0/6 0/5 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6
 Day 3 0/22 0/6 0/6 1/5 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6
 Day 28 0/24 0/6 0/6 1/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 1/6 0/6
Hyperplasia of connective tissue near bile ductless or venules
 Day 1 0/12 0/6 0/5 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6
 Day 3 0/22 0/6 0/6 1/5 0/5 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 1/6
 Day 28 0/24 0/6 1/6 1/6 0/6 0/6 0/6 0/6 0/6 1/6 0/6 1/6 2/6 2/6
Microfoci of necrosis
 Day 1 0/12 1/6 0/5 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6
 Day 3 0/22 0/6 0/6 1/5 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 2/6 1/6
 Day 28 0/24 1/6 2/6 2/6 0/6 0/6 0/6 0/6 0/6 1/6 0/6 1/6 1/6 1/6
Eosinophilic necrosis of single hepatocytes
 Day 1 0/12 0/6 0/5 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6
 Day 3 0/22 0/6 1/6 1/5 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6
 Day 28 0/24 2/6 1/6 2/6 0/6 0/6 0/6 1/6 0/6 1/6 0/6 1/6 1/6 1/6
Hepatocytes with pyknotic nuclei
 Day 1 0/12 0/6 0/5 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6
 Day 3 0/22 0/6 1/6 1/5 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 1/6
 Day 28 0/24 1/6 2/6 2/6 0/6 0/6 0/6 1/6 0/6 1/6 1/6 1/6 2/6 1/6
Parenchymatous degeneration
 Day 1 0/12 0/6 0/5 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6
 Day 3 0/22 0/6 1/6 1/5 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 1/6
 Day 28 0/24 1/6 2/6 2/6 0/6 1/6 0/6 0/6 1/6 1/6 0/6 2/6 2/6 2/6
Vacuolar degeneration
 Day 1 0/12 0/6 1/5 2/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 2/6 2/6 0/6
 Day 3 0/22 2/6 2/6 3/5 0/6 0/6 1/6 0/6 1/6 2/6 1/6 2/6 3/6 2/6
 Day 28 0/24 1/6 2/6 2/6 0/6 0/6 1/6 0/6 3/6 3/6 0/6 3/6 2/6 2/6
Binucleate hepatocytes
 Day 1 1/12 2/6 1/5 1/6 0/6 0/6 0/6 1/6 1/6 0/6 1/6 0/6 1/6 0/6
 Day 3 1/22 1/6 2/6 2/5 1/6 2/6 1/6 0/6 1/6 2/6 1/6 2/6 1/6 2/6
 Day 28 2/24 2/6 2/6 3/6 1/6 1/6 1/6 2/6 1/6 1/6 2/6 1/6 2/6 2/6
Oedematous endothelial cells of portal venules or close to blood vessels
 Day 1 0/12 0/6 0/5 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6
 Day 3 0/22 0/6 0/6 1/5 0/6 0/6 0/6 0/6 0/6 1/6 0/6 0/6 0/6 1/6
 Day 28 0/24 0/6 2/6 2/6 0/6 0/6 0/6 0/6 1/6 1/6 0/6 1/6 2/6 2/6
Increased number (hyperplasia) of Kupffer cells
 Day 1 0/12 0/6 0/5 1/6 1/6 0/6 1/6 0/6 0/6 0/6 0/6 0/6 1/6 0/6
 Day 3 0/22 1/6 1/6 2/5 0/6 0/6 0/6 0/6 2/6 2/6 1/6 1/6 1/6 1/6
 Day 28 0/24 1/6 2/6 1/6 0/6 0/6 1/6 1/6 1/6 1/6 1/6 1/6 2/6 1/6
Hypertrophy of Kupffer cells
 Day 1 0/12 0/6 2/5 2/6 0/6 0/6 0/6 0/6 0/6 1/6 2/6 2/6 2/6 0/6
 Day 3 0/22 0/6 3/6 2/5 0/6 1/6 1/6 1/6 2/6 1/6 1/6 2/6 1/6 0/6
 Day 28 0/24 1/6 2/6 3/6 0/6 0/6 1/6 0/6 1/6 1/6 0/6 2/6 2/6 1/6
Hyperplasia of bile ducts epithelium
 Day 1 0/12 0/6 0/5 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6
 Day 3 0/22 1/6 2/6 1/5 0/6 0/6 0/6 0/6 0/6 0/6 1/6 0/6 1/6 0/6
 Day 28 0/24 1/6 1/6 1/6 0/6 0/6 1/6 1/6 1/6 1/6 2/6 2/6 1/6 2/6