|
Variable
|
Number of fetuses
|
Median [Q1; Q3]
|
Fully adjusted linear model
|
|---|
|
C
|
E
|
C
|
E
|
β value
|
CI
|
P-value
|
|---|
|
Fetal weight (g)
|
41
|
68
|
38.5 [36.0; 41.7]
|
34.45 [31.1; 37.8]
|
−1.895
|
[−5.362;1.571]
|
0.307
|
|
Crown-rump length (cm)
|
41
|
68
|
12.0 [11.6; 12.5]
|
11.7 [11.1; 12.1]
|
−0.107
|
[−0.494;0.28]
|
0.596
|
|
Biparietal diameter (mm)
|
41
|
66
|
17.9 [17.5; 18.2]
|
17.2 [16.3; 17.8]
|
−0.697
|
[−1.649;0.256]
|
0.178
|
|
Head length (mm)
|
41
|
66
|
29.5 [28.7; 30.2]
|
28.4 [27.4; 29]
|
−1.293
|
[−2.301;-0.2285]
|
0.029*
|
|
Abdominal perimeter (cm)
|
41
|
67
|
7.5 [7.3; 8.0]
|
7.2 [6.8; 7.5]
|
−0.529
|
[−1.058;0]
|
0.076
|
|
Brain weight (g)
|
40
|
68
|
0.92 [0.88; 0.96]
|
0.93 [0.86; 0.96]
|
0.011
|
[−0.055;0.077]
|
0.746
|
|
Brain/Fetus weight ratio
|
40
|
68
|
0.025 [0.023; 0.028]
|
0.027 [0.025; 0.030]
|
0.002
|
[−0.001;0.004]
|
0.241
|
|
Lung/Fetus weight ratio
|
39
|
66
|
0.029 [0.027; 0.031]
|
0.030 [0.028; 0.032]
|
0
|
[−0.001;0.002]
|
0.570
|
|
Heart/Fetus weight ratio
|
41
|
68
|
0.006 [0.005; 0.006]
|
0.005 [0.005; 0.006]
|
0
|
[0;0.001]
|
0.662
|
|
Liver/Fetus weight ratio
|
41
|
68
|
0.066 [0.063; 0.072]
|
0.068 [0.062; 0.071]
|
−0.002
|
[−0.007;0.003]
|
0.514
|
|
Kidney/Fetus weight ratio
|
39
|
64
|
0.0006 [0.0006; 0.0007]
|
0.0006 [0.0005; 0.0007]
|
0
|
[0;0]
|
0.999
|
|
Placental weight (g)
|
41
|
68
|
7.32 [6.64; 8.43]
|
7.51 [6.83; 8.57]
|
0.153
|
[−0.794;1.1]
|
0.756
|
|
Labyrinthine area weight (g)
|
41
|
66
|
5.03 [4.41; 5.92]
|
4.99 [4.34; 6.05]
|
−0.17
|
[−1.003;0.663]
|
0.695
|
|
Decidual weight (g)
|
41
|
66
|
2.16 [1.98; 2.56]
|
2.51 [2.14; 2.96]
|
0.307
|
[−0.164;0.778]
|
0.226
|
|
Placental efficiency
|
41
|
68
|
5.29 [4.65; 5.51]
|
4.64 [3.92; 5.00]
|
−0.63
|
[−1.187;-0.074]
|
0.049*
|
- Female rabbits inhaled 1 mg/m3 of NP, 2 h/day, 5 days/week, from 3 dpc to 27 dpc. Dams were euthanized and fetoplacental units of control (C) and exposed (E) group were collected at 28 dpc. Effect of pregnancy exposure to engine diesel exhaust on first-generation fetuses was estimated using a linear model with random effect of dam adjusted for litter size and position of the fetus in the horn. All data are expressed as median [Q1; Q3] (*p < 0.05, compared with control group)
