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Table 2 Fetoplacental biometry at 28 dpc for the first generation

From: Maternal exposure to diluted diesel engine exhaust alters placental function and induces intergenerational effects in rabbits

Variable

Number of fetuses

Median [Q1; Q3]

Fully adjusted linear model

C

E

C

E

β value

CI

P-value

Fetal weight (g)

41

68

38.5 [36.0; 41.7]

34.45 [31.1; 37.8]

−1.895

[−5.362;1.571]

0.307

Crown-rump length (cm)

41

68

12.0 [11.6; 12.5]

11.7 [11.1; 12.1]

−0.107

[−0.494;0.28]

0.596

Biparietal diameter (mm)

41

66

17.9 [17.5; 18.2]

17.2 [16.3; 17.8]

−0.697

[−1.649;0.256]

0.178

Head length (mm)

41

66

29.5 [28.7; 30.2]

28.4 [27.4; 29]

−1.293

[−2.301;-0.2285]

0.029*

Abdominal perimeter (cm)

41

67

7.5 [7.3; 8.0]

7.2 [6.8; 7.5]

−0.529

[−1.058;0]

0.076

Brain weight (g)

40

68

0.92 [0.88; 0.96]

0.93 [0.86; 0.96]

0.011

[−0.055;0.077]

0.746

Brain/Fetus weight ratio

40

68

0.025 [0.023; 0.028]

0.027 [0.025; 0.030]

0.002

[−0.001;0.004]

0.241

Lung/Fetus weight ratio

39

66

0.029 [0.027; 0.031]

0.030 [0.028; 0.032]

0

[−0.001;0.002]

0.570

Heart/Fetus weight ratio

41

68

0.006 [0.005; 0.006]

0.005 [0.005; 0.006]

0

[0;0.001]

0.662

Liver/Fetus weight ratio

41

68

0.066 [0.063; 0.072]

0.068 [0.062; 0.071]

−0.002

[−0.007;0.003]

0.514

Kidney/Fetus weight ratio

39

64

0.0006 [0.0006; 0.0007]

0.0006 [0.0005; 0.0007]

0

[0;0]

0.999

Placental weight (g)

41

68

7.32 [6.64; 8.43]

7.51 [6.83; 8.57]

0.153

[−0.794;1.1]

0.756

Labyrinthine area weight (g)

41

66

5.03 [4.41; 5.92]

4.99 [4.34; 6.05]

−0.17

[−1.003;0.663]

0.695

Decidual weight (g)

41

66

2.16 [1.98; 2.56]

2.51 [2.14; 2.96]

0.307

[−0.164;0.778]

0.226

Placental efficiency

41

68

5.29 [4.65; 5.51]

4.64 [3.92; 5.00]

−0.63

[−1.187;-0.074]

0.049*

  1. Female rabbits inhaled 1 mg/m3 of NP, 2 h/day, 5 days/week, from 3 dpc to 27 dpc. Dams were euthanized and fetoplacental units of control (C) and exposed (E) group were collected at 28 dpc. Effect of pregnancy exposure to engine diesel exhaust on first-generation fetuses was estimated using a linear model with random effect of dam adjusted for litter size and position of the fetus in the horn. All data are expressed as median [Q1; Q3] (*p < 0.05, compared with control group)