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Table 3 Fetal metabolism at 28 dpc for the first generation

From: Maternal exposure to diluted diesel engine exhaust alters placental function and induces intergenerational effects in rabbits

Variable Number of fetuses Median [Q1; Q3] Fully adjusted linear model
C E C E β value CI P-value
Glycemia (mmol/L) 16 20 4.250 [3.200; 4.675] 4.210 [3.150; 5.358] 0.401 [−0.794;1.597] 0.521
Insulin (mUI/L) 17 19 1.800 [1.300; 2.950] 1.000 [0.700; 1.400] −0.998 [−1.886;-0.111] 0.050*
Total cholesterol (mmol/L) 17 20 1.950 [1.640; 2.620] 2.115 [1.818; 2.455] 0.013 [−0.436;0.462] 0.956
HDL cholesterol (mmol/L) 17 20 0.460 [0.433; 0.498] 0.400 [0.360; 0.490] 0.035 [−0.03;0.099] 0.309
Non-HDL cholesterol (mmol/L) 17 20 1.590 [1.275; 2.165] 1.645 [1.388; 1.948] −0.022 [−0.412;0.369] 0.915
Triglycerids (mmol/L) 15 20 0.570 [0.460; 0.670] 0.585 [0.445; 0.870] 0.062 [−0.238;0.362] 0.689
ASAT (UI/L) 17 20 168.0 [86.50; 184.5] 171.5 [129.3; 217.5] 26.413 [−19.769;72.594] 0.284
ALAT (UI/L) 10 16 7.000 [6.000; 9.500] 9.000 [7.000; 9.750] 1.18 [−1.068;3.428] 0.326
Creatinine (μmol/L) 17 20 87.00 [84.50; 91.00] 95.00 [92.00; 104.8] 7.329 [−3.003;17.662] 0.190
Urea (mmol/L) 17 20 5.600 [5.150; 5.850] 6.500 [5.425; 7.450] 0.841 [−0.369;2.05] 0.199
IGF-1 (nmol/L) 20 20 1.184 [0.337; 2.368] 0.108 [0.000; 1.581] −0.105 [−0.179;-0.031] 0.019*
  1. Effect of exposure to engine diesel exhaust on first-generation fetuses was estimated using a linear model with random effect of dam adjusted for litter size and position of the fetus in the horn. All data are expressed as median [Q1; Q3] (*p < 0.05, **p < 0.01, compared with control group)
  2. ASAT ASpartate Amino Transferase, ALAT ALanine Amino Transferase