TY - JOUR AU - Breznan, Dalibor AU - Karthikeyan, Subramanian AU - Phaneuf, Marcelle AU - Kumarathasan, Prem AU - Cakmak, Sabit AU - Denison, Michael S. AU - Brook, Jeffrey R. AU - Vincent, Renaud PY - 2016 DA - 2016/08/12 TI - Development of an integrated approach for comparison of in vitro and in vivo responses to particulate matter JO - Particle and Fibre Toxicology SP - 41 VL - 13 IS - 1 AB - Association of particulate matter with adverse health effects has been established in epidemiological studies and animal experiments. Epidemiological studies are difficult to undertake while animal studies are impractical for high-throughput toxicity testing. The ease and rapidity of in vitro tests emphasizes their potential for use in risk assessment of chemicals and particles. We examined the association between in vitro and in vivo responses to ambient particles, to determine the potential of cell-based assays as standalone toxicity screening tools. SN - 1743-8977 UR - https://doi.org/10.1186/s12989-016-0152-6 DO - 10.1186/s12989-016-0152-6 ID - Breznan2016 ER -