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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Development of an integrated approach for comparison of in vitro and in vivo responses to particulate matter

Fig. 1

Lactate Dehydrogenase (LDH) release into cell culture supernatants of J774A.1 (a) and A549 (b) cells exposed for 24 h to particles, and Aryl hydrocarbon receptor (AhR) induction by particles in the H1L1.1c2 cells after a 4 h exposure (c). For the LDH assay, data represent LDH release, adjusted for total cellular LDH content. For the AhR assay, B[a]P was used as a positive control (0, 1, 10, 100 nM). All values are presented as average fold-effect (FE) over control ± standard error (J774A.1, n = 4; A549, n = 3; H1L1.1c2, n = 3). Two way ANOVA; J774A.1, PM × Dose interaction, p < 0.001, asterisks (*) represent effects significantly different from Dose 0 control, Tukey test, p < 0.05; A549, PM × Dose interaction, p < 0.001, asterisks (*) represent effects significantly different from Dose 0 control, Tukey test, p < 0.05. Two way ANOVA; AhR, PM × Dose interaction, p < 0.001, asterisks (*) represent effects significantly different from Dose 0 control, Tukey test, p < 0.05; one way ANOVA; B(a)P, Concentration, p = 0.016, Conc. 100 vs. 1 (†), Tukey test, p < 0.05

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