Fig. 1From: Development of an integrated approach for comparison of in vitro and in vivo responses to particulate matterLactate Dehydrogenase (LDH) release into cell culture supernatants of J774A.1 (a) and A549 (b) cells exposed for 24 h to particles, and Aryl hydrocarbon receptor (AhR) induction by particles in the H1L1.1c2 cells after a 4 h exposure (c). For the LDH assay, data represent LDH release, adjusted for total cellular LDH content. For the AhR assay, B[a]P was used as a positive control (0, 1, 10, 100 nM). All values are presented as average fold-effect (FE) over control ± standard error (J774A.1, n = 4; A549, n = 3; H1L1.1c2, n = 3). Two way ANOVA; J774A.1, PM × Dose interaction, p < 0.001, asterisks (*) represent effects significantly different from Dose 0 control, Tukey test, p < 0.05; A549, PM × Dose interaction, p < 0.001, asterisks (*) represent effects significantly different from Dose 0 control, Tukey test, p < 0.05. Two way ANOVA; AhR, PM × Dose interaction, p < 0.001, asterisks (*) represent effects significantly different from Dose 0 control, Tukey test, p < 0.05; one way ANOVA; B(a)P, Concentration, p = 0.016, Conc. 100 vs. 1 (†), Tukey test, p < 0.05Back to article page