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Fig. 2 | Particle and Fibre Toxicology

Fig. 2

From: Development of an integrated approach for comparison of in vitro and in vivo responses to particulate matter

Fig. 2

Heatmap with hierarchical cluster analysis of cytotoxic potency of particles in J774A.1 and A549 cells based on cytotoxicity assays (LDH release, AB reduction, ATP content, BrdU incorporation) and AhR induction in H1L1.1c2 cells. Within the heatmap, green color represents increased cytotoxic potency of particles (negative β) for majority of endpoints, except the AhR assay, where red color depicts increased potency (positive β) (a). Consensus cytotoxic potency βV CELLS was calculated for each particle as average of all assay potencies, separately, for J774A.1 and A549 cells. AhR induction potencies of the particles in H1L1.1c2 cells are also presented (b)

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