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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Development of an integrated approach for comparison of in vitro and in vivo responses to particulate matter

Fig. 5

Biological reactivity estimate, βR CELLS was derived by averaging the cytotoxic potencies of the particles in A549 and J774A.1 cells, as well as the AhR activity in H1L1.1c2 cells (a). A combined inflammatory estimate, βI-V CELLS, was obtained for each particle by averaging particle inflammatory potency estimates adjusted for cell viability of J774A.1 and A549 cells. The βI-V LO represents the lower estimate (IL-10 and IL-6 potency subtracted from average potency), while βI-V HI is the higher estimate (IL-10 potency subtracted, IL-6 added to average potency) (b). An integrated potency estimate of the particles, Iβ CELLS was determined by averaging the biological reactivity (cytotoxic potency) and inflammatory estimates for each particle. Iβ LO represents the lower estimate (IL-10 and IL-6 potency subtracted from average potency). Iβ HI represents the higher estimate (IL-10 potency subtracted, IL-6 added to average potency) (c)

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