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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Development of an integrated approach for comparison of in vitro and in vivo responses to particulate matter

Fig. 7

Interleukin (IL)-6 (a) levels in BAL. All values are presented as mean fold effect (FE) over control ± standard error (n = 5). Two way ANOVA; IL-6, PM × Dose interaction, p = 0.036, asterisks (*) represent effects significantly different from Dose 0 control, Tukey test, p < 0.05. Heatmap with hierarchical cluster analysis of the individual inflammatory mediators (cytokines/chemokines) (b) assessed in BALB/c mice 24 h after exposure to particles by intratracheal instillation, summarized as potency estimates (β from the cytokine dose response). Within the heatmaps, red color represents increased inflammatory potency of particles (increased cytokine/chemokine levels; positive β), whereas green color represents decreased inflammatory potency (negative β)

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