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Fig. 8 | Particle and Fibre Toxicology

Fig. 8

From: Development of an integrated approach for comparison of in vitro and in vivo responses to particulate matter

Fig. 8

Toxic potency estimate in BALB/c, βT BALB/c was derived by averaging the potencies of the particles across the cell-specific and biochemical measures from BALB/c mice exposed to the particles by intratracheal instillation (a). The combined inflammatory potency estimate, βI BALB/c, was obtained for each particle by averaging the particle potencies for altered cytokine/chemokine levels in bronchioalveolar lavage. The βI LO represents the lower estimate (IL-10 and IL-6 potency subtracted from average potency). The βI HI represents the higher estimate (IL-10 potency subtracted, IL-6 added to average potency) (b). The integrated potency estimate, Iβ BALB/c of the particles was determined by averaging the toxic and inflammatory potency estimates for each individual particle. The Iβ LO represents the lower estimate (IL-10 and IL-6 potency subtracted from average potency), while Iβ HI is the higher estimate (IL-10 potency subtracted, IL-6 added to average potency) (c)

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