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Table 6 Rank order correlations for the combined in vitro (cell lines) and in vivo (BALB/c mouse) particle potency estimates for all particles (PM) and excluding cristobalite (CRI)

From: Development of an integrated approach for comparison of in vitro and in vivo responses to particulate matter

Particle potency estimates Particles Ranking in vitro Ranking in vivo Rank-order correl. (All PM)a Rank-order correl. (no CRI)b
R p (1-tailed) R p (1-tailed)
Toxicity
 βR CELLS vs. βT BALB/c
CRI 5 - 3 -     
DWR1 4 (4) 5 (4)     
EHC-2000 2 (2) 2 (2) 0.667 0.109 1.000 <0.001
SRM-1649 1 (1) 1 (1)     
TiO2 3 (3) 4 (3)     
Inflammation
 βI-V CELLS vs. βI BALB/c
CRI 4 - 3 -     
DWR1 5 (4) 5 (4)     
EHC-2000 1 (1) 2 (2) 0.800 0.052 0.800 0.100
SRM-1649 2 (2) 1 (1)     
TiO2 3 (3) 4 (3)     
Integrated Potency
 Iβ CELLS vs. Iβ BALB/c
CRI 4 - 3 -     
DWR1 5 (4) 5 (4)     
EHC-2000 1 (1) 2 (2) 0.800 0.052 0.800 0.100
SRM-1649 2 (2) 1 (1)     
TiO2 3 (3) 4 (3)     
  1. Particle ranking based on integrated particle potency estimates across cell types and in vitro or in vivo endpoints, where the lowest number represents the most potent particle
  2. The ranking outside brackets includes all PM, the ranking within brackets excludes CRI
  3. aSpearman’s rank-order correlation and p-values (1-tailed) on ranked corresponding in vitro and in vivo potency estimates for all PM, bexcluding CRI
  4. Numbers in bold represent statistically significant correlations (p ≤ 0.05)
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