Long-term exposure to commercially available sunscreens containing nanoparticles of TiO2 and ZnO revealed no biological impact in a hairless mouse model

Table 4 Top 5 canonical transcriptional pathways perturbed in treated, relative to untreated, mice from Series 1

Group ID	Sunscreen	UVR (kJ/m²)	Top 5 canonical pathways
Control + UVR	None	29	Role of BRCA1 in DNA Damage Response; Cholecystokinin/Gastrin-Mediated Signalling; ATM Signalling; NF-kB Signalling; DNA Double-Strand Break Repair by Non-Homologous End Joining
ZnO-UVR	ZnO	0	No statistically significant differentially expressed genes identified
ZnO + UVR	ZnO	29	No statistically significant differentially expressed genes identified
TiO₂-UVR	TiO₂	0	No statistically significant differentially expressed genes identified
TiO₂ + UVR	TiO₂	29	Circadian Rhythm Signalling; Tetrapyrrole Biosynthesis II; Heme Biosynthesis II; Breast Cancer Regulation by Stathmin1; Mevalonate Pathway I
Organic-UVR	Organic	0	Estrogen Receptor Signalling; UVA-induced MAPK Signalling; All-trans-decaprenyl Diphosphate Biosynthesis; Remodelling of Epithelial Adherens Junctions; Phosphatidylethanolamine Biosynthesis II
Organic + UVR	Organic	29	Protein Ubiquitination Pathway; tRNA Charging; Estrogen Receptor Signalling; Remodelling of Epithelial Adherens Junctions; EIF2 Signalling

ISSN: 1743-8977