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Fig. 12 | Particle and Fibre Toxicology

Fig. 12

From: Differential pulmonary effects of CoO and La2O3 metal oxide nanoparticle responses during aerosolized inhalation in mice

Fig. 12

Schematic image showing the toxicity mechanisms of CoO and La2O3 nanoparticles. The redox potential of CoO nanoparticles falls into the biological redox potential (BRP), which allows electrons to transfer from biological molecules to CoO nanoparticles. This process could induce oxidative stress, leading to mitochondria damage, cell death and acute lung toxicity. In contrast, no electrons were transferred from biological system to La2O3 nanoparticles. However, La2O3 nanoparticles could transform into sea urchin LaPO4 in lysosomes, induce lysosomal damage, cathepsin B release, NLRP3 inflammasome activation and IL-1β production, which finally results in chronic lung inflammation and fibrosis

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