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Fig. 2 | Particle and Fibre Toxicology

Fig. 2

From: In vivo biodistribution and physiologically based pharmacokinetic modeling of inhaled fresh and aged cerium oxide nanoparticles in rats

Fig. 2

Schematic representation of the nanoparticle PBPK model developed in this study for inhalation, with sub-compartments of phagocytizing cells (PCs) in each tissue. Arrows represent the direction of various pathways for the nanoparticles to migrate from one location to another. Nanoparticles may not be endocytosed by PCs nor migrate into the tissue matrix and exist in a “free” state in the tracheobronchial and pulmonary region of the lung

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