Skip to main content

Table 1 Description and values for non-inhalation specific pharmacokinetics parameters. Values in bold are fitted a

From: In vivo biodistribution and physiologically based pharmacokinetic modeling of inhaled fresh and aged cerium oxide nanoparticles in rats

Parameter (unit) Description Generic values b Spleen (s) Liver (l) Lungs (lu) Heart (h) Kidneys (k) GI tract (gi) Brain (br) Rest of the body (rest) Blood (blood)
W t /WB (unitless) b % of organ weight to body weight - 0.0031 0.0396 0.0047 0.0034 0.0094 0.044 0.0053 0.84 0.0498
W t,b /W t (unitless) c % of capillary blood in organ to organ weight - 0.225 0.156 0.1 0.175 0.316 0.1 0.07 0.017 -
frQ t (unitless) d Fraction of cardiac output to organ - 0.0146 0.0465 1 0.051 0.141 0.213 0.02 0.514 1
N t (# per g) d Phagocytizing cells number per organ weight - 2.08 × 108 2.72 × 107 2.69 × 106, 3.90 × 10 6± 3.71 × 10 2 g 7.60 × 104 9.90 × 104 5.06 × 10 5± 2.22 × 10 3 3.06 × 105 8.11 × 106 1.85 × 103
M cap (μg per #) f Maximum uptake capacity in individual phagocytizing cells 5.52 × 10 −7± 6.98 × 10 −11 - - - - - - - - -
χ α (unitless) f Permeability coefficient between blood and tissue 7.76 × 10 −1± 2.14 × 10 −4 Generic Generic Generic Generic Generic Generic 6.75 × 10 −7± 8.84 × 10 −11 1.71 × 10 −2± 6.54 × 10 −7 -
P (unitless) f Partition coefficient between tissue and blood 2.09 × 10 −1± 9.83 × 10 −7 Generic Generic Generic Generic Generic Generic Generic Generic 1
k ab0 (per h) f Maximum uptake rate by phagocytizing cells 1.45 × 10 0± 4.62 × 10 −5 5.18 × 10 −1± 5.87 × 10 −5 Generic Generic Generic Generic Generic Generic Generic Generic
k de (per h) f Desorption rate by phagocytizing cells 5.30 × 10 −19± 1.24 × 10 −17 Generic Generic Generic Generic Generic Generic Generic Generic Generic
CLE e (per h) Clearance rate to excreta - - 1.52 × 10 −3± 6.97 × 10 −6 - - 3.26 × 10 0± 2.70 × 10 −3 1.41 × 10 −1± 8.42 × 10 −7 - - -
fr β (unitless) e, f Fraction of capillary blood of organs left when analyzed 0.144 Generic Generic Generic Generic Generic Generic 0.371 Generic -
  1. a “-” stands for not applicable
  2. b Values were obtained by from Wenger et al. [45] except for the GI tract, which was obtained from Bernareggi and Rowland [42]
  3. c Values were obtained from literature estimates of the percentage (w/w) of capillary blood in the organs [41] except for lungs and GI tract, which were estimated by the authors
  4. d Values obtained from literature [15, 42, 43]
  5. e Values obtained from Carlander et al. [35]
  6. f M cap , χα, P, k ab0 , k de, fr β have generic values for most compartments. “generic” indicates the corresponding generic value for each parameter
  7. g 2.69 × 106 is for the lungs interstitium, 3.90 × 106 ± 3.71 × 102 is for the pulmonary region of the lungs
\