Table 2 Description and values for inhalation specific pharmacokinetics parameters All values are fitted
Parameter (unit) | Description | Value |
|---|---|---|
fr ua (unitless) | Fraction of inhaled nanoparticles deposited in the upper airway | 2.11 × 10−1 ± 8.54 × 10−7 |
fr tra (unitless) | Fraction of inhaled nanoparticles deposited in the tracheobronochial region | 1.75 × 10−2 ± 1.23 × 10−7 |
fr pul (unitless) | Fraction of inhaled nanoparticles deposited in the pulmonary region | 4.36 × 10−2 ± 4.08 × 10−8 |
k giab (per h) | Absorption rate of GI tract | 5.41 × 10−3 ± 7.38 × 10−8 |
k uabr (per h) | Transfer rate from upper airway to brain | 8.36 × 10−5 ± 1.34 × 10−9 |
k uagi (per h) | Transfer rate from upper airway to GI tract lumen | 3.35 × 10−1 ± 2.24 × 10−6 |
k tragi (per h) | Transfer rate from tracheobronchial region to GI tract lumen | 5.52 × 10−3 ± 1.22 × 10−6 |
k pulmtra (per h) | Transfer rate of inactive phagocytizing cells from pulmonary region to tracheobronchial region | 8.65 × 10−4 ± 4.74 × 10−7 |
k lupi (per h) | Transfer rate from pulmonary region to interstitium of lungs | 1.26 × 10−1 ± 3.47 × 10−5 |
k luip (per h) | Transfer rate from interstitium of lungs to pulmonary region | 1.12 × 10−6 ± 2.49 × 10−6 |
delay gi (h) | Time delay for nanoparticles to travel from respiratory system to GI tract | 1.88 × 100 ± 8.02 × 10−5 |
delay f (h) | Time delay for nanoparticles in feces to be excreted out | 7.9 × 100 ± 1.04 × 10−1 |