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Table 2 Description and values for inhalation specific pharmacokinetics parameters All values are fitted

From: In vivo biodistribution and physiologically based pharmacokinetic modeling of inhaled fresh and aged cerium oxide nanoparticles in rats

Parameter (unit) Description Value
fr ua (unitless) Fraction of inhaled nanoparticles deposited in the upper airway 2.11 × 10−1 ± 8.54 × 10−7
fr tra (unitless) Fraction of inhaled nanoparticles deposited in the tracheobronochial region 1.75 × 10−2 ± 1.23 × 10−7
fr pul (unitless) Fraction of inhaled nanoparticles deposited in the pulmonary region 4.36 × 10−2 ± 4.08 × 10−8
k giab (per h) Absorption rate of GI tract 5.41 × 10−3 ± 7.38 × 10−8
k uabr (per h) Transfer rate from upper airway to brain 8.36 × 10−5 ± 1.34 × 10−9
k uagi (per h) Transfer rate from upper airway to GI tract lumen 3.35 × 10−1 ± 2.24 × 10−6
k tragi (per h) Transfer rate from tracheobronchial region to GI tract lumen 5.52 × 10−3 ± 1.22 × 10−6
k pulmtra (per h) Transfer rate of inactive phagocytizing cells from pulmonary region to tracheobronchial region 8.65 × 10−4 ± 4.74 × 10−7
k lupi (per h) Transfer rate from pulmonary region to interstitium of lungs 1.26 × 10−1 ± 3.47 × 10−5
k luip (per h) Transfer rate from interstitium of lungs to pulmonary region 1.12 × 10−6 ± 2.49 × 10−6
delay gi (h) Time delay for nanoparticles to travel from respiratory system to GI tract 1.88 × 100 ± 8.02 × 10−5
delay f (h) Time delay for nanoparticles in feces to be excreted out 7.9 × 100 ± 1.04 × 10−1
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