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Table 3 Measured concentrations of CeO2 nanoparticles at different post exposure time (ng/g) a, b

From: In vivo biodistribution and physiologically based pharmacokinetic modeling of inhaled fresh and aged cerium oxide nanoparticles in rats

Organ Fresh 1, filter packs based concentration 172 μg/m3, SMPS based <70 nm concentration 27.9 μg/m3 Fresh 2 c, filter packs based concentration 585 μg/m3, SMPS based <70 nm concentration 38.9 μg/m3 Aged 1, filter packs based concentration 483 μg/m3, SMPS based <70 nm concentration 26.4 μg/m3 Aged 2, filter packs based concentration 439 μg/m3, SMPS based <70 nm concentration 35.6 μg/m3
  15 min 1 day 7 day 15 min 1 day 7 day 15 min 1 day 7 day 15 min 1 day 7 day
Blood 3.10 ± 0.88 2.90 ± 0.22 1.85 ± 0.07 2.36 ± 0.33 2.32 ± 0.11 2.10 ± 0.35 1.50 ± 0.13 1.76 ± 0.24 0.91 ± 0.33 1.16 ± 0.29 0.57 ± 0.09 0.91 ± 0.35
Lungs 317 ± 129 225 ± 31 93.9 ± 129 1593 ± 144 935 ± 1317 1014 ± 1417 1307 ± 391 495 ± 469 775 ± 325 953 ± 758 1421 ± 250 929 ± 317
Spleen 0.92 ± 0.74 0.21 ± 0.07 2.26 ± 2.73 0.12 ± 0.05 0.46 ± 0.16 3.14 ± 4.39 0.34 ± 0.25 0.27 ± 0.02 0.38 ± 0.09 1.19 ± 0.07 1.55 ± 0.46 1.92 ± 0.24
Liver 0.49 ± 0.12 1.47 ± 0.22 6.65 ± 4.62 0.95 ± 0.22 1.55 ± 1.49 4.46 ± 5.63 0.31 ± 0.21 1.27 ± 0.99 6.36 ± 2.81 0.32 ± 0.15 1.63 ± 0.55 3.57 ± 0.64
Kidneys 0.22 ± 0.06 0.99 ± 0.35 1.67 ± 0.43 0.94 ± 0.03 1.41 ± 0.81 3.47 ± 3.21 0.24 ± 0.09 0.58 ± 0.11 1.73 ± 0.40 1.20 ± 0.16 1.93 ± 0.18 2.96 ± 0.54
GI tract - - - - - - 63.0 ± 30.4 1.26 ± 12.8 9.78 ± 4.95 34.4 ± 13.4 24.4 ± 20.4 8.95 ± 6.19
Heart 0.13 ± 0.03 0.37 ± 0.38 0.33 ± 0.06 0.61 ± 0.14 0.56 ± 0.13 0.66 ± 0.28 0.25 ± 0.19 0.49 ± 0.45 0.25 ± 0.07 1.36 ± 0.13 1.32 ± 0.15 1.47 ± 0.05
Brain 0.16 ± 0.01 5.55 ± 8.91 0.77 ± 0.11 1.11 ± 0.17 0.95 ± 0.03 1.42 ± 0.19 0.34 d BDL BDL 1.64 ± 0.47 1.83 ± 0.76 1.41 ± 0.29
Olfactory bulb 0.69 ± 0.07 0.84 ± 0.08 0.69 ± 0.29 13.0 ± 10.6 5.92 ± 3.65 4.69 ± 1.71 BDL BDL BDL BDL 0.92 d BDL
Feces - 91.6 ± 4.3 - - 769 ± 431 - - 672 ± 431 - - 656 ± 117 -
Urine - 5.79 ± 3.37 - - - - - 1.66 ± 1.26 - - 1.98 ± 2.06 -
  1. a All values displayed are mean ± standard deviation (n = 3)
  2. b “BDL” stands for below detection limit; “-” stands for no samples
  3. c The exposure duration for experiment fresh 2 was 6 h, instead of 4 h for all other experiments. Please refer to text for more details
  4. d Only one sample was above detection limit
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