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Table 3 Measured concentrations of CeO2 nanoparticles at different post exposure time (ng/g) a, b

From: In vivo biodistribution and physiologically based pharmacokinetic modeling of inhaled fresh and aged cerium oxide nanoparticles in rats

Organ

Fresh 1, filter packs based concentration 172 μg/m3, SMPS based <70 nm concentration 27.9 μg/m3

Fresh 2 c, filter packs based concentration 585 μg/m3, SMPS based <70 nm concentration 38.9 μg/m3

Aged 1, filter packs based concentration 483 μg/m3, SMPS based <70 nm concentration 26.4 μg/m3

Aged 2, filter packs based concentration 439 μg/m3, SMPS based <70 nm concentration 35.6 μg/m3

 

15 min

1 day

7 day

15 min

1 day

7 day

15 min

1 day

7 day

15 min

1 day

7 day

Blood

3.10 ± 0.88

2.90 ± 0.22

1.85 ± 0.07

2.36 ± 0.33

2.32 ± 0.11

2.10 ± 0.35

1.50 ± 0.13

1.76 ± 0.24

0.91 ± 0.33

1.16 ± 0.29

0.57 ± 0.09

0.91 ± 0.35

Lungs

317 ± 129

225 ± 31

93.9 ± 129

1593 ± 144

935 ± 1317

1014 ± 1417

1307 ± 391

495 ± 469

775 ± 325

953 ± 758

1421 ± 250

929 ± 317

Spleen

0.92 ± 0.74

0.21 ± 0.07

2.26 ± 2.73

0.12 ± 0.05

0.46 ± 0.16

3.14 ± 4.39

0.34 ± 0.25

0.27 ± 0.02

0.38 ± 0.09

1.19 ± 0.07

1.55 ± 0.46

1.92 ± 0.24

Liver

0.49 ± 0.12

1.47 ± 0.22

6.65 ± 4.62

0.95 ± 0.22

1.55 ± 1.49

4.46 ± 5.63

0.31 ± 0.21

1.27 ± 0.99

6.36 ± 2.81

0.32 ± 0.15

1.63 ± 0.55

3.57 ± 0.64

Kidneys

0.22 ± 0.06

0.99 ± 0.35

1.67 ± 0.43

0.94 ± 0.03

1.41 ± 0.81

3.47 ± 3.21

0.24 ± 0.09

0.58 ± 0.11

1.73 ± 0.40

1.20 ± 0.16

1.93 ± 0.18

2.96 ± 0.54

GI tract

-

-

-

-

-

-

63.0 ± 30.4

1.26 ± 12.8

9.78 ± 4.95

34.4 ± 13.4

24.4 ± 20.4

8.95 ± 6.19

Heart

0.13 ± 0.03

0.37 ± 0.38

0.33 ± 0.06

0.61 ± 0.14

0.56 ± 0.13

0.66 ± 0.28

0.25 ± 0.19

0.49 ± 0.45

0.25 ± 0.07

1.36 ± 0.13

1.32 ± 0.15

1.47 ± 0.05

Brain

0.16 ± 0.01

5.55 ± 8.91

0.77 ± 0.11

1.11 ± 0.17

0.95 ± 0.03

1.42 ± 0.19

0.34 d

BDL

BDL

1.64 ± 0.47

1.83 ± 0.76

1.41 ± 0.29

Olfactory bulb

0.69 ± 0.07

0.84 ± 0.08

0.69 ± 0.29

13.0 ± 10.6

5.92 ± 3.65

4.69 ± 1.71

BDL

BDL

BDL

BDL

0.92 d

BDL

Feces

-

91.6 ± 4.3

-

-

769 ± 431

-

-

672 ± 431

-

-

656 ± 117

-

Urine

-

5.79 ± 3.37

-

-

-

-

-

1.66 ± 1.26

-

-

1.98 ± 2.06

-

  1. a All values displayed are mean ± standard deviation (n = 3)
  2. b “BDL” stands for below detection limit; “-” stands for no samples
  3. c The exposure duration for experiment fresh 2 was 6 h, instead of 4 h for all other experiments. Please refer to text for more details
  4. d Only one sample was above detection limit