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Table 4 Sensitivity coefficients of important nanoparticle-specific parameters (four experiments averages, <−0.3 or >0.3 bolded)

From: In vivo biodistribution and physiologically based pharmacokinetic modeling of inhaled fresh and aged cerium oxide nanoparticles in rats

Parameter Blood Lungs Liver Spleen Kidneys Heart Brain GI tract Urine Feces
CLE fgi a −0.08 0.00 −0.65 −0.62 −0.64 −0.46 −0.17 −0.92 −0.66 0.08
M cap 0.86 0.01 −0.13 −0.09 −0.12 −0.07 −0.02 −0.01 −0.16 0.00
k ab0 −0.02 0.07 0.19 −0.75 0.14 0.10 0.02 0.00 −0.81 0.00
k giab 0.08 0.00 0.69 0.66 0.67 0.49 0.18 0.03 0.70 −0.04
k uagi 0.00 0.00 0.01 0.01 0.01 −0.23 −0.72 0.00 0.01 0.02
P −0.05 0.00 0.52 0.49 0.48 0.34 0.12 0.04 −0.46 0.00
χ rest b −0.05 0.00 −0.39 −0.39 −0.36 −0.27 −0.08 −0.02 −0.41 0.00
fr ua 0.08 0.00 0.69 0.66 0.68 0.67 0.98 0.92 0.70 0.97
fr pul 0.06 0.76 0.42 0.42 0.43 0.42 0.00 0.05 0.44 0.00
  1. a Clearance rate from GI tract to feces
  2. b Permeability coefficient between blood to rest of the body
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