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Table 4 Sensitivity coefficients of important nanoparticle-specific parameters (four experiments averages, <−0.3 or >0.3 bolded)

From: In vivo biodistribution and physiologically based pharmacokinetic modeling of inhaled fresh and aged cerium oxide nanoparticles in rats

Parameter

Blood

Lungs

Liver

Spleen

Kidneys

Heart

Brain

GI tract

Urine

Feces

CLE fgi   a

−0.08

0.00

−0.65

−0.62

−0.64

−0.46

−0.17

−0.92

−0.66

0.08

M cap

0.86

0.01

−0.13

−0.09

−0.12

−0.07

−0.02

−0.01

−0.16

0.00

k ab0

−0.02

0.07

0.19

−0.75

0.14

0.10

0.02

0.00

−0.81

0.00

k giab

0.08

0.00

0.69

0.66

0.67

0.49

0.18

0.03

0.70

−0.04

k uagi

0.00

0.00

0.01

0.01

0.01

−0.23

−0.72

0.00

0.01

0.02

P

−0.05

0.00

0.52

0.49

0.48

0.34

0.12

0.04

−0.46

0.00

χ rest   b

−0.05

0.00

−0.39

−0.39

−0.36

−0.27

−0.08

−0.02

−0.41

0.00

fr ua

0.08

0.00

0.69

0.66

0.68

0.67

0.98

0.92

0.70

0.97

fr pul

0.06

0.76

0.42

0.42

0.43

0.42

0.00

0.05

0.44

0.00

  1. a Clearance rate from GI tract to feces
  2. b Permeability coefficient between blood to rest of the body