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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Mesothelioma response to carbon nanotubes is associated with an early and selective accumulation of immunosuppressive monocytic cells

Fig. 1

M-MDSC are specifically accumulated in the peritoneal cavity of rats bearing mesotheliomas after carcinogenic CNT-7 exposure. Incidence of peritoneal mesotheliomas (a). Flow cytometry dot plots show the proportions of peritoneal leukocyte sub-populations (b) present in the peritoneal cavity of Wistar rats bearing or not mesotheliomas after carcinogenic CNT-7 (6 mg) or saline (Ctl) treatments and identified by using CD11b/c and His48 markers (a = macrophages, b = M-MDSC, c = neutrophils, d = granulocytes, i.e. eosinophils and mast cells, as indicated in CNT-7 square). Proportion of (c) monocytic CD11b/cint and His48high Myeloid Derived Suppressor Cells (M-MDSC) (see b in B), (d) CD11b/cint and His48int neutrophils (see c in B), (e) CD11b/chigh and His48int macrophages (see a in B), and (f) CD11b/cint and His48low granulocytic cells (see d in B, eosinophils-mast cells) in peritoneal fluid after saline, CNT-7, short CNT-7 (6 mg) or asbestos (Asb, 2 mg) intra-peritoneally injected in rats. Each bar represents mean ± SEM. The results were statistically analyzed using the Dunnett’s Multiple Comparison test. ** = p < 0.01, *** = p < 0.001 indicate a statistically significant difference with saline-treated rats (Ctl)

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