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Table 3 Calculated pharmacological values for coronary artery ring constrictor and relaxation response

From: Impact of pulmonary exposure to gold core silver nanoparticles of different size and capping agents on cardiovascular injury

Treatment Group EC50 (nM) Hill slope
5-HT ACh SNP 5-HT ACh SNP
 Naive 87.7 ± 26.7 103.3 ± 28.7 20.0 ± 4.3 1.3 ± 0.1 1.8 ± 0.2 1.1 ± 0.1
1 Day Post IT Exposure
 Citrate 105.9 ± 17.1 75.6 ± 7.4 31.0 ± 5.3 1.3 ± 0.1 1.7 ± 0.1 1.2 ± 0.1
 20 nm AgNP 60.2 ± 8.4 132.8 ± 56.8 22.0 ± 3.4 1.5 ± 0.1 1.5 ± 0.1 1.1 ± 0.1
 110 nm AgNP 75.5 ± 16.3 147.6 ± 51.0 28.1 ± 4.8 1.4 ± 0.1 1.6 ± 0.1 1.1 ± 0.1
 PVP 79.5 ± 11.5 115.7 ± 30.5 20.9 ± 3.4 1.4 ± 0.1 1.7 ± 0.2 1.2 ± 0.1
 20 nm AgNP 95.1 ± 20.1 95.3 ± 3.0 18.9 ± 3.2 1.4 ± 0.1 1.5 ± 0.0 1.2 ± 0.1
 110 nm AgNP 70.0 ± 10.2a 147.6 ± 51.0 23.0 ± 2.4 1.3 ± 0.1 1.8 ± 0.2 1.1 ± 0.1
7 Day Post IT Exposure
 Citrate 799.6 ± 395.9 57.4 ± 1.2 67.1 ± 33.9 1.2 ± 0.4 1.5 ± 0.0 1.0 ± 0.1
 20 nm AgNP 264.2 ± 74.9 112.9 ± 29.0 55.7 ± 8.2 1.1 ± 0.2 1.6 ± 0.2 1.1 ± 0.1
 110 nm AgNP 954.6 ± 80.8 98.3 ± 11.6 59.3 ± 12.5 1.1 ± 0.2 1.9 ± 0.1 1.3 ± 0.3
 PVP 237.7 ± 61.1 89.2 ± 25.9 48.8 ± 3.6 1.1 ± 0.2 1.6 ± 0.3 1.2 ± 0.1
 20 nm AgNP 140.8 ± 31.3 117.5 ± 26.3 41.0 ± 3.6 1.2 ± 0.2 1.5 ± 0.1 1.0 ± 0.1
 110 nm AgNP 306.0 ± 70.3a 110.2 ± 39.4 50.7 ± 13.3 1.1 ± 0.2 1.6 ± 0.2 1.2 ± 0.1
  1. The calculated mean EC50 and Hill slope, responses of LAD coronary artery segment to serotonin (5-HT), acetylcholine (ACh), and sodium nitroprusside (SNP) 1 day and 7 days following 200 μl instillation of Citrate or PVP vehicle or 200 μg 20 or 110 nm AgNP. Values expressed mean ± SEM. adenotes significant versus Naïve (p < 0.05) calculated by one-way ANOVA with Tukey Post Hoc test, n = 3–8