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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: The role of hypoxia-inducible factor-1α in zinc oxide nanoparticle-induced nephrotoxicity in vitro and in vivo

Fig. 6

In vivo biodistribution of ZnO NPs and histopathological analysis of kidneys after i.p. injection of ZnO NPs. a The images of liver, lungs, kidneys, spleen and heart under NIR illumination clearly demonstrate the presence of ZnO NPs in these organs. BALB/c mice were i.p. injected with red-NIR700-ZnO NPs (a dose of 10 mg/kg) and were sacrificed 6 h after injection. Various organs were collected, and fluorescence imaging was conducted using an IVIS 200 imaging system. b Concentration of ZnO NPs in tissues. The mice were i.p. injected with ZnO NPs (a dose of 10 mg/kg) and were sacrificed 6 h after injection. The concentrations of Zn in the lung, kidney, liver, spleen and heart were evaluated using an ICP-AES. *p < 0.05 versus control. c Histopathological kidney lesions were found in ZnO NP-treated mice. Tissue sections were stained with H&E and observed microscopically. The black arrows indicate tubular dilatation. The black arrowheads indicate the loss of brush borders and flattened tubular epithelium. The asterisks indicate the reduction of Bowman’s space and the increase in cellularity in glomeruli. BS, bowman space; G, glomerulus

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