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Table 2 Biochemical tests including BUN, creatinine, GOT and GPT after i.p. injection of ZnO NPs

From: The role of hypoxia-inducible factor-1α in zinc oxide nanoparticle-induced nephrotoxicity in vitro and in vivo

Item/Group 0 mg/kg 1 mg/kg 2 mg/kg 4 mg/kg
BUN (mg/dL) 18.76 ± 3.75 23.46 ± 3.06 19.38 ± 0.57 23.40 ± 1.67*
Creatinine (mg/dL) 0.26 ± 0.02 0.33 ± 0.02* 0.33 ± 0.03* 0.35 ± 0.04*
GOT (U/L) 114.20 ± 22.13 116.40 ± 17.77 153.20 ± 27.40* 168.60 ± 29.53*
GPT (U/L) 31.80 ± 0.84 32.00 ± 3.32 34.40 ± 2.88 36.40 ± 1.52*
  1. *p < 0.05, ZnO NPs versus control