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Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: Lung carcinogenicity of inhaled multi-walled carbon nanotube in rats

Fig. 3

Macroscopic and microscopic findings of the lungs and peritoneal pleura. a Lung from a control male rat. b Multiple white areas and nodules in the lungs of a 2 mg/m3 MWNT-7-exposed male. c Bronchiolo-alveolar carcinoma in the lung of the male rat exposed to 2 mg/m3 MWNT-7. Carcinoma cells invaded the wall of the vein. Bar, 50 μm. d Bronchiolo-alveolar carcinoma in the lung of a female rat exposed to 2 mg/m3 MWNT-7. Proliferation of carcinoma cells accompanied by fibrous connective tissue is causing the disappearance of the existing alveolar construction. Bar, 50 μm. e Atypical hyperplasia accompanied by proliferative fibrous connective tissue and MWNT-7 deposition in the lung of a female rat exposed to 2 mg/m3 MWNT-7. Epithelial cell polarity is poorly defined and the nuclei of the cells vary in size. Bar, 30 μm. f The left image shows the normal parietal pleura of a control male rat. The right image shows a simple mesothelial hyperplasia of the parietal pleura in a male rat exposed to 2 mg/m3 MWNT-7. Bar, 25 μm

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