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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy

Fig. 1

SiO2 induced autophagy via MCPIP1. a Representative western blot showing the effects of SiO2 (50 μg/cm2) on the expression of the autophagy markers BECN and LC3B in U937 cells. b Densitometric analyses of five separate experiments suggested that SiO2 induced increases in BECN and LC3B expression. *p < 0.05 vs BECN expression at 0 h; #p < 0.05 vs LC3B expression at 0 h. c Representative immunocytochemical images showing that SiO2 (50 μg/cm2) increased the expression of LC3B in U937 cells at 24 h following SiO2 treatment. Scale bar = 20 μm. d Representative western blot showing the effects of SiO2 on the expression of MCPIP1 and p53 in U937 cells. e Densitometric analyses of five separate experiments suggested that SiO2 induced increases in MCPIP1 and p53 expression. *p < 0.05 vs MCPIP1 expression at 0 h; #p < 0.05 vs p53 expression at 0 h

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