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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy

Fig. 5

SiO2-induced macrophage autophagy was involved in HPF-a cell activation. a Representative western blot showing the effects of conditioned media from macrophages treated with SiO2 on Bax and Bcl-xL expression in HPF-a cells. b Densitometric analyses of five separate experiments suggested that the conditioned media from macrophages in the SiO2 group decreased the Bax/Bcl-xL level in HPF-a cells. *p < 0.05 vs the control group. c.Representative western blot showing the effects of conditioned media from macrophages on collagen I, collagen III and α-SMA expression in HPF-a cells. d Densitometric analyses of five separate experiments suggested that the conditioned media from macrophages in the SiO2 group increased the expression of collagen I, collagen III and α-SMA in HPF-a cells. *p < 0.05 vs the corresponding control group

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