Fig. 8

Autophagy was increased in macrophages from silicosis patients. a Representative western blot showing the expression of BECN and LC3B in macrophages from healthy donors and silicosis patients. b Densitometric analyses of macrophage samples from five healthy donors and five silicosis patients suggested that BECN and LC3B expression was elevated in macrophages from silicosis patients. *p < 0.05 vs the corresponding healthy control group. c Representative western blot showing the expression of MCPIP1 and p53 in macrophages from healthy donors and silicosis patients. d Densitometric analyses of macrophage samples from five healthy donors and five silicosis patients suggested that MCPIP1 and p53 expression was elevated in macrophages from silicosis patients. *p < 0.05 vs the corresponding healthy control group. e Representative western blot showing the expression of iNOS, Arginase 1 and SOCS3 in macrophages from healthy donors and silicosis patients. f Densitometric analyses of macrophage samples from five healthy donors and five silicosis patients suggested that iNOS, Arginase 1 and SOCS3 expression was increased in macrophages from silicosis patients. *p < 0.05 vs the corresponding healthy control group. g Representative western blot showing the expression of Bax and Bcl-xL in macrophages from healthy donors and silicosis patients. h Densitometric analyses of macrophage samples from five healthy donors and five silicosis patients suggested that the Bax/Bcl-xL level was elevated in macrophages from silicosis patients. *p < 0.05 vs the healthy control group