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Table 1 Physiochemical characterization

From: Comparative toxicity and biodistribution assessments in rats following subchronic oral exposure to copper nanoparticles and microparticles

Items Cu NPs Cu MPs
Shape Spherical Spherical
Primary sizea 32.7 ± 10.5 nm 25.3 ± 6.6 μm
Hydrodynamic size (nm)b pH 1.5 n.a n.a
pH 6.5 516 ± 116.9 n.a
pH 7.8 334 ± 128.3 n.a
Surface area (m2/g)c 14.7 0.16
Zeta potential (mV)d pH 1.5 25.5 ± 0.8 n.a
pH 6.5 1.32 ± 1.2 n.a
pH 7.8 −6.2 ± 0.2 n.a
  1. Note
  2. aPrimary size of Cu NPs and Cu MPs was measured by transmission electron microscopy (300 counts and 100 counts, respectively)
  3. bHydrodynamic size of Cu NPs was measured by a dynamic light scattering method
  4. cSurface area was measured by the Brunauer-Emmett-Teller method (N2 gas)
  5. dZeta potential was measured using electrophoretic light scattering method under pH 1.5, pH 6.5 and pH 7.8 conditions
  6. n.a. not available