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Table 2 Hematological changes in male rats treated with Cu NPs and Cu MPs following 28 days-repeated oral dose

From: Comparative toxicity and biodistribution assessments in rats following subchronic oral exposure to copper nanoparticles and microparticles

Items

Cu NPs (mg/kg/day)

0

100

200

400

No. of rats

10

10

10

10

RBC (1012/L)

7.02 ± 0.234a

6.69 ± 0.388

6.17 ± 0.346**

6.12 ± 0.612**

HB (g/dL)

16.78 ± 1.212

15.77 ± 1.668

12.70 ± 1.628**

11.80 ± 1.187**

HCT (%)

43.43 ± 3.435

42.50 ± 2.432

37.32 ± 3.179**

36.47 ± 5.747**

MCV (fl)

53.73 ± 4.388

50.09 ± 4.618

43.63 ± 9.582**

43.60 ± 4.486**

MCH (pg)

23.47 ± 1.598

21.31 ± 2.788

19.10 ± 3.306**

18.92 ± 2.099**

MCHC (g/dL)

34.68 ± 2.770

34.57 ± 3.317

33.05 ± 4.339

28.31 ± 2.198**

PLT (109/L)

1106.2 ± 104.92

1212.7 ± 125.88

1258.8 ± 166.73*

1262.4 ± 121.65*

RET (%)

2.3 ± 0.23

2.4 ± 0.51

2.7 ± 0.48

6.1 ± 2.17**

WBC (109/L)

11.2 ± 0.95

11.3 ± 2.13

8.5 ± 3.03*

8.3 ± 1.21**

NEU (%)

11.9 ± 0.95

11.2 ± 3.45

23.9 ± 5.41**

36.6 ± 8.15**

LYM (%)

82.3 ± 10.73

82.3 ± 12.79

71.7 ± 13.28

52.7 ± 20.17**

MON (%)

2.2 ± 0.39

2.2 ± 0.33

2.3 ± 0.51

3.0 ± 0.59**

EOS (%)

1.7 ± 0.39

1.7 ± 0.33

1.6 ± 0.53

2.0 ± 0.59

BAS (%)

0.7 ± 0.21

0.8 ± 0.18

0.7 ± 0.27

0.7 ± 0.19

LUC (%)

0.7 ± 0.13

0.7 ± 0.24

1.0 ± 0.19*

1.2 ± 0.25**

Items

Cu MPs (mg/kg/day)

 

0

100

200

400

No. of rats

10

10

10

10

RBC (1012/L)

7.04 ± 0.312

7.20 ± 0.286

7.00 ± 0.403

6.96 ± 0.388

HB (g/dL)

16.65 ± 1.326

16.72 ± 1.169

15.96 ± 1.563

16.12 ± 1.971

HCT (%)

43.79 ± 4.793

43.61 ± 4.201

40.16 ± 5.776

41.63 ± 3.304

MCV (fl)

53.81 ± 5.716

52.70 ± 6.621

52.63 ± 4.184

52.34 ± 7.206

MCH (pg)

23.61 ± 3.392

24.32 ± 2.562

24.52 ± 1.397

22.93 ± 4.257

MCHC (g/dL)

34.71 ± 3.392

29.67 ± 5.561

32.09 ± 3.397

32.25 ± 4.257

PLT (109/L)

1179.7 ± 202.53

1047.4 ± 218.36

1259.8 ± 187.54

1236.5 ± 232.71

RET (%)

2.5 ± 0.58

2.6 ± 0.37

2.4 ± 0.39

2.7 ± 0.44

WBC (109/L)

11.3 ± 1.49

11.9 ± 2.48

12.3 ± 3.49

11.56 ± 2.23

NEU (%)

12.2 ± 2.23

10.8 ± 3.91

13.2 ± 4.45

11.9 ± 3.71

LYM (%)

82.9 ± 13.2

85.0 ± 22.47

82.7 ± 16.66

83.5 ± 13.09

MON (%)

2.2 ± 0.48

2.3 ± 0.31

2.5 ± 0.43

2.3 ± 0.54

EOS (%)

1.6 ± 0.42

1.5 ± 0.24

1.6 ± 0.40

1.8 ± 0.48

BAS (%)

0.7 ± 0.23

0.7 ± 0.17

0.8 ± 0.13

0.7 ± 0.21

LUC (%)

0.7 ± 0.22

0.9 ± 0.29

0.9 ± 0.29

0.9 ± 0.23

  1. Note. RBC red blood cell, HB hemoglobin, HCT hematocrit, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, PLT platelet, RET reticulocytes, NEU neutrophils, LYM lymphocytes, MON monocytes, EOS eosinophils, BAS basophils, LUC large unstained cells
  2. aValues are presented as mean ± SD
  3. *, ** P < 0.05, P < 0.01 versus vehicle control group
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Particle and Fibre Toxicology

ISSN: 1743-8977

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