Particle and Fibre Toxicology

Table 5 Lowest observed adverse effect levels (LOAELs in μg/cm²) determined with the pro-inflammatory effects for each exposure method used

From: Air-liquid interface exposure to aerosols of poorly soluble nanomaterials induces different biological activation levels compared to exposure to suspensions

	IL-1β			IL-6			IL-8			TNF-α
	ALI^a	Subm insert^b	Subm plate^c	ALI^a	Subm insert^b	Subm plate^c	ALI^a	Subm insert^b	Subm plate^c	ALI^a	Subm insert^b	Subm plate^b
NM105	1	3	10	1	10	20	1	3	Ø	1	3	20
NM101	1	10	10	1	3	10	1	3	Ø	1	3	10
NM100	Ø	Ø	Ø	3	3	Ø	1	Ø	Ø	Ø	Ø	Ø
NM212	3	Ø	Ø	3	Ø	Ø	1	10	Ø	Ø	10	Ø

^aExposure at the air-liquid interface in inserts (ALI)
^bExposure in submerged conditions in inserts
^cExposure in submerged conditions in plates
Ø No effects measured at tested doses

Back to article page

ISSN: 1743-8977

Contact us

General enquiries: journalsubmissions@springernature.com