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Table 5 Lowest observed adverse effect levels (LOAELs in μg/cm2) determined with the pro-inflammatory effects for each exposure method used

From: Air-liquid interface exposure to aerosols of poorly soluble nanomaterials induces different biological activation levels compared to exposure to suspensions

  IL-1β IL-6 IL-8 TNF-α
  ALIa Subm insertb Subm platec ALIa Subm insertb Subm platec ALIa Subm insertb Subm platec ALIa Subm insertb Subm plateb
NM105 1 3 10 1 10 20 1 3 Ø 1 3 20
NM101 1 10 10 1 3 10 1 3 Ø 1 3 10
NM100 Ø Ø Ø 3 3 Ø 1 Ø Ø Ø Ø Ø
NM212 3 Ø Ø 3 Ø Ø 1 10 Ø Ø 10 Ø
  1. aExposure at the air-liquid interface in inserts (ALI)
  2. bExposure in submerged conditions in inserts
  3. cExposure in submerged conditions in plates
  4. Ø No effects measured at tested doses