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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Endocytosed nanoparticles hold endosomes and stimulate binucleated cells formation

Fig. 6

Expressions and distributions of Rab11 and EEA1. a: Western blotting revealed that the amount of proteins of Rab11 and EEA1 increased along the co-culturing time (from 10 min, 30 min to 50 min). b: (a) Red fluorescent spots of Rab11 accumulated at the midbody in control cell of mitosis telophase, (b) the red fluorescent spots accumulated to large clusters beside the midbody in treated cell of mitosis telophase. c: (a) Red fluorescent spots of EEA1 mainly focused at the midbody in control cell of mitosis telophase, (b) the red fluorescent spots were less at the midbody and accumulated to large clusters at the poles of treated cell of mitosis telophase. d: Fluorescence intensities of Rab11 and EEA1 at midbody were lower obviously after co-cultured with 30 nm Ps particles. Comparted with control, the difference of Rab11 was significance (p < 0.05) and EEA1 was without significance in treated cell. Distributions of these key regulators (EEA1 and Rab11) which regulate the organizing of contractile ring and cytokinesis were disturbed obviously

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