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Fig. 12 | Particle and Fibre Toxicology

Fig. 12

From: Surface area-dependence of gas-particle interactions influences pulmonary and neuroinflammatory outcomes

Fig. 12

Vasculature mRNA expression in the hippocampus of C57BL/6 and ApoE−/− mice after acute and chronic exposure to atmospheres. Expression of Vcam-1 mRNA was determined after acute exposures in the (a) hippocampus of C57BL/6 mice and (b) hippocampus of ApoE−/− mice. The only significant effect was that of acute exposure to FP on Vcam-1 in the ApoE−/− hippocampus. Expression of Vcam-1 mRNA was determined after chronic exposures in the (c) hippocampus of C57BL/6 mice and (d) hippocampus of ApoE−/− mice. UFP + G and FP significantly increased Vcam-1 expression in the C57BL/6 hippocampus after 30 days of exposure. n = 7–8 per group, *p < .05; **p < .01; ***p < .001

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