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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Surface area-dependence of gas-particle interactions influences pulmonary and neuroinflammatory outcomes

Fig. 7

Cytokine protein expression profile in bronchial lavage fluid after chronic (30-day) exposure to atmospheres. After 30-days of exposure to the atmospheres, bronchial lavage fluid (BALF) was obtained from animals and assessed for cytokine protein expression for the (a) CXCL1 in C57BL/6 BALF, (b) TNF-α in C57BL/6 BALF, (c) CXCL1 in ApoE−/− BALF and (d) TNF-α in ApoE−/− BALF. The most significant changes were induced by exposure to UFP + G: (a) CXCL1 expression in C57BL/6 animals, (b) TNF-α expression in C57BL/6 animals, (c) CXCL1 expression in ApoE−/− animals, and (d) TNF-α expression in ApoE−/− were all significantly increased in after chronic exposure to UFP + G. (e) CXCL1 expression was significantly increased in C57BL/6 animals in response to UFP + G compared to ApoE−/− animals. n = 7–8 per group, *p < .05; **p < .01; ***p < .001; ****p < .0001

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