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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Early kidney damage induced by subchronic exposure to PM2.5 in rats

Fig. 6

Kidney antioxidants decreased at the end of the eight weeks of PM2.5 exposure. After eight exposure weeks (4 days/week, 5 h/ day) in kidney rats we observed a decrement of the antioxidant nuclear transcription factor (Nrf-2) (a), and antioxidant enzymes such as mitochondrial superoxide dismutase (SOD-2) and hemoxygenase type-1 (HO-1), (b) and (c) respectively. However, the gamma-glutamil cysteine ligase heavy chain the catalytic subunit (γ-GCLc) was up-regulated showed the kidney dependence of glutathione resource (d) On boxplot graphyc * indicates statistical differences (p < 0.05)

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