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Fig. 8 | Particle and Fibre Toxicology

Fig. 8

From: Early kidney damage induced by subchronic exposure to PM2.5 in rats

Fig. 8

Exposure to PM2.5 induces an early pro-fibrosis state. After eight exposure weeks (4 days/week, 5 h/ day) in kidney rat we observed the promotion of fibrosis by the detection of beta- transforming growth factor (TGF-β) (a) and the evaluation of pro-collagen-III mRNA (Col3a1) by q-PCR, (b) Premature deposit of collagen in tubular and glomerulli by the Masson’s trichromic staining (c). Yellow and red arrows indicate deposit of colagen in control (FA) and PM2.5 groups, respectivetly. On boxplot graphic *indicates statistical differences (p < 0.05)

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