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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Dose-dependent induction of astrocyte activation and reactive astrogliosis in mouse brain following maternal exposure to carbon black nanoparticle

Fig. 6

Expression levels of mRNA in the cerebral cortices of offspring. Expression levels of mRNA selected from microarray data and the gene annotation analysis were analyzed by quantitative reverse transcription-polymerase chain reaction. Relative expression levels of the target genes were calculated for each sample after normalization against Gapdh. A one-way ANOVA followed by post hoc Dunnett tests revealed significant increases in Flt1 (a), Sox17 (d), Tgfa (f), and Cyr61 (h) gene expression in the cerebral cortices of high-dose group offspring compared to the control group. *p < 0.05, **p < 0.01 vs. control. Kdr (b), Nos3 (c), and Tbx1 (e) showed non-significant increases in gene expression in the cerebral cortices of high-dose group offspring compared to the control group. Up-regulation of Tie1 (g) and Cxcl12 (i) gene expression was not observed in each groups

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Particle and Fibre Toxicology

ISSN: 1743-8977

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