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Table 4 Results of mRNA expression in tracheal epithelial cells after CBNP exposure

From: Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons

 

P90

P90-BaP

P90-9NA

AS-PAH

10 μg/ml

30 μg/ml

10 μg/ml

30 μg/ml

10 μg/ml

30 μg/ml

10 μg/ml

30 μg/ml

KC

1.1 ± 0.2

1.1 ± 0.2

1.2 ± 0.2

0.7 ± 0.2

1.3 ± 0.2

1.2 ± 0.3

3.8 ± 1.5*

2.4 ± 0.6*

IL-6

0.7 ± 0.2

0.8 ± 0.1

1.0 ± 0.2

0.6 ± 0.1*

1.3 ± 0.3

0.7 ± 0.1*

2.0 ± 0.8

2.6 ± 0.4*

Gpx3

2.2 ± 0.9

0.7 ± 0.1*

0.8 ± 0.2

0.8 ± 0.1

1.7 ± 0.7

0.7 ± 0.1

5.2 ± 3.8

1.3 ± 0.5

Gr

0.7 ± 0.1*

0.7 ± 0.1*

1.0 ± 0.1

1.0 ± 0.1

1.4 ± 0.2

1.0 ± 0.2

1.5 ± 0.3

1.7 ± 0.5

Cyp1a1

1.4 ± 0.4

0.8 ± 0.3

331 ± 22*

1289 ± 412*

2.0 ± 1.0

30 ± 9*

1157 ± 232*

2442 ± 452*

Cyp1b1

0.2 ± 0.1*

0.2 ± 0.0*

5.3 ± 1.0*

10.9 ± 2.4*

1.3 ± 0.1

2.5 ± 0.6*

11.1 ± 4.3*

4.3 ± 0.7*

  1. Data show the n-fold mRNA expression after CBNP exposure compared to medium controls. Exposure time was 24 h. Data are mean ± SEM. n = 5–7, *p < 0.05 CBNP compared to medium controls analyzed by Wilcoxon signed-rank test
  2. Gpx3 Glutathione peroxidase 3, Gr Glutathione reductase, KC keratinocyte chemoattractant, IL-6 interleukine-6, Cyp1a1/Cyp1b1 Cytochrome P450 subtypes 1a1 and 1b1