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Table 2 BAL fluid cell counts in mice, 4, 6 and 8 weeks post-exposure to 0, 2, 17 or 67 ug of MWCNT NM-400

From: Airway exposure to multi-walled carbon nanotubes disrupts the female reproductive cycle without affecting pregnancy outcomes in mice

  

Absolute cell numbers

Percentage of cell type in sample (%)

Dose level of MWCNT

 Control

2 μg

18 μg

67 μg

 Control

 2 μg

18 μg

67 μg

4 wks

N

4

9

9

6

4

9

9

6

 

Neutrophils (×103)

7.8 ± 2.9

13.1 ± 7.6

272 ± 168

1173 ± 318b

1.1 ± 0.5

1.7 ± 0.9

10.9 ± 3.7

16.2 ± 3.3a

Macrophages (×103)

785 ± 190

607 ± 46

1073 ± 219

4468 ± 662c

83.1 ± 2.7

75.7 ± 2.8

76.9 ± 3.7

66.8 ± 4.6

Eosinophils (×103)

25.2 ± 12

54.5 ± 40

5.7 ± 2.4

106 ± 34

3.9 ± 2.3

4.3 ± 2.8

0.3 ± 0.1

1.4 ± 0.4

Lymphocytes (×103)

0.7 ± 0.7

2.0 ± 1.5

6.8 ± 3.4

103 ± 52

0.1 ± 0.1

0.2 ± 0.1

0.7 ± 0.3

1.4 ± 0.6

Total BAL cells (×103)

927 ± 195

821 ± 80

1511 ± 400

6855 ± 1095

-

-

-

-

Epithelial cells (×103)

109 ± 25

144 ± 11

153 ± 29

1013 ± 230c

11.8 ± 2.0

18.2 ± 1.2

11.2 ± 2.2

14.4 ± 1.9

Dead cells (×103)

237 ± 53

240 ± 23

280 ± 47

943 ± 115

-

-

-

-

6 wks

 N

 10

8 

6 

10 

 10

8 

6 

10 

 

Neutrophils (×103)

5.9 ± 3.0

5.3 ± 2.2

274 ± 118

2503 ± 792c

0.6 ± 0.3

0.8 ± 0.3

9.3 ± 2.7

27.8 ± 5.4c

Macrophages (×103)

802 ± 175

750 ± 123

1867 ± 780

4685 ± 1426b

89.2 ± 1.0

94.1 ± 1.1

79.5 ± 3.7

63.2 ± 4.4c

Eosinophils (×103)

18.8 ± 11

1.8 ± 0.7

7.1 ± 57

15.2 ± 13a

1.7 ± 0.9

0.3 ± 0.1

0.2 ± 0.1

0.1 ± 0.1

Lymphocytes (×103)

0.3 ± 0.3

1.4 ± 1.0

26.4 ± 2.5

98.5 ± 46

0.1 ± 0.1

0.2 ± 0.1

1.8 ± 0.6b

1.5 ± 0.5a

Total BAL cells (×103)

898 ± 197

793 ± 124

2313 ± 942

7781 ± 2218b

-

-

-

-

Epithelial cells (×103)

71.6 ± 14

34.7 ± 5.4

186 ± 55

479 ± 137b

8.6 ± 1.3

4.7 ± 0.8

9.3 ± 1.7a

7.4 ± 1.1

Dead cells (×103)

121 ± 43

121 ± 35

281 ± 131

840 ± 186c

-

-

-

-

8 wks

N

 12

3

3

13 

 12

3

3

13 

 

Neutrophils (×103)

10.1 ± 3.8

0.0 ± 0.0

400 ± 169

986 ± 261b

1.4 ± 0.5

0.0 ± 0.0

20.3 ± 4.5

22.8 ± 4.2c

Macrophages (×103)

633 ± 89

458 ± 33

1453 ± 678

2346 ± 470b

82.7 ± 2.0

85.5 ± 9.0

73.2 ± 2.8

63.8 ± 3.6c

Eosinophils (×103)

2.8 ± 1.6

49.8 ± 48

10.6 ± 5.7

25.6 ± 12

0.4 ± 0.2

8.5 ± 8.3a

0.7 ± 0.4

0.8 ± 0.3

Lymphocytes (×103)

0.7 ± 0.8

1.8 ± 0.9

35.2 ± 31

49.6 ± 1.4b

0.1 ± 0.1

0.3 ± 0.2

1.2 ± 0.7

1.5 ± 0.5a

Total BAL cells (×103)

784 ± 130

540 ± 153

2013 ± 945

3830 ± 733b

-

-

-

-

Epithelial cells (×103)

137 ± 40

30.9 ± 5.1

113 ± 8.0

422 ± 108

15.4 ± 1.9

5.7 ± 0.7a

4.7 ± 1.5a

11.0 ± 1.3

Dead cells (×103)

174 ± 59

43.7 ± 29

251 ± 63

479 ± 93

-

-

-

-

  1. Mean ± SEM. a, b, c: Statistically significant compared to control mice at the 0.5, 0.01 and 0.001 level, respectively