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Fig. 12 | Particle and Fibre Toxicology

Fig. 12

From: Osteopontin enhances multi-walled carbon nanotube-triggered lung fibrosis by promoting TGF-β1 activation and myofibroblast differentiation

Fig. 12

Regulation of fibrotic protein expression by OPN and TGF-β1 in lung fibroblasts exposed to MWCNTs. Cells were treated with DM, 5 μg/ml MWCNTs, or 5 μg/ml MWCNTs with TGF-β1 neutralizing antibodies, TGF-β receptor inhibitor SB525334, or OPN neutralizing antibodies for 24 h. (a) Levels of Collagen I (red) and FN1 (red) were examined by immunofluorescence. Blue indicates nuclear staining (scale bar: 20 μm). (b) Induction of Collagen I in myofibroblasts by MWCNTs was examined by double immunofluorescence staining of Collagen I (red) and α-SMA (green). Blue indicates nuclear staining (scale bar: 20 μm)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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