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Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: Early pulmonary response is critical for extra-pulmonary carbon nanoparticle mediated effects: comparison of inhalation versus intra-arterial infusion exposures in mice

Fig. 3

Hematological analysis of blood samples following inhalation and intra-arterial infusion of carbon nanoparticle (CNP) in mice compared to control. CNP exposure related changes are shown as percentage relative to control. a. Granulocyte and monocyte numbers were increased in the blood following 24 h CNP inhalation exposure. [Granulocytes: 0.46 ± 0.09 versus 0.75 ± 0.05 × 10E3; Monocytes: 0.04 ± 0.01 versus 0.07 ± 0.01 × 10E3 cells/ml blood]. Platelet counts, particularly that of large platelets, were significantly increased both after 4 h and 24 h post exposure periods. [Platelet (4 h post exposure): 810 ± 87 versus 1203 ± 55; Platelet (24 h post exposure): 869 ± 97 versus 1104 ± 18 and Large platelet (4 h post exposure): 1.9 ± 0.4 versus 17.6 ± 2.7; Large platelet (24 h post exposure): 4.3 ± 1.3 versus 9.0 ± 1.3 x10E3 cells/ml blood]. b. Intra-arterial infusion of CNP resulted in increased lymphocyte counts after 4 h [Lymphocyte: 1.52 ± 0.07 versus 1.92 ± 0.13 x10E3 cells/ml blood] but the platelet count remained unaltered. Data are shown as Mean ± SEM; inhalation: n = 8, infusion: n = 6 and asterisks (*) denote p < 0.05. WBC: White blood cell; Neutro: neutrophilic granulocytes; Mono: Monocytes; Lympho: Lymphocytes; RBC: Red blood cells; PLT: Platelets; Large PLT: Large platelets

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Particle and Fibre Toxicology

ISSN: 1743-8977

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