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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Early pulmonary response is critical for extra-pulmonary carbon nanoparticle mediated effects: comparison of inhalation versus intra-arterial infusion exposures in mice

Fig. 6

Heatmap representation of the transcript (59 genes) and protein (34 analytes) panel profiling from heart, aorta and liver following carbon nanoparticle (CNP) inhalation (4 h and 24 h) and intra-arterial infusion (4 h) comparing exposed versus control mice. a. Transcript expression levels of 59 genes representing epithelial/endothelial activation, inflammatory cell markers, inflammation mediators and oxidative stress of heart, aorta and liver are shown. b. Protein expression levels of 34 markers representing epithelial/endothelial activation, inflammatory cell markers, inflammation mediators of heart and liver are shown. Samples were pooled from 4 animals/experimental group for transcript and protein analysis. Expression values are provided as percentage relative to time matched control. Fold changes below 1.5 were considered insignificant and are indicated in black color. Ox. stress: Oxidative Stress

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