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Table 3 Lung burden and clearance half-times of exposed rats

From: Effects from a 90-day inhalation toxicity study with cerium oxide and barium sulfate nanoparticles in rats

 

Lung burden (μg/lung ± SD)

Clearance t1/2 (days)

d 1

d 28

d 90 + 1rec

d 90 + 28rec

d 90 + 90rec

Clean air

1.2 ± 1.0

0.6 ± 0.2

1.8 ± 0.8

0.8 ± 0.5

1.3 ± 1.3

-

0.1 mg/m3 CeO2

2.5 ± 0.8

12.0 ± 2.9

33.1 ± 1.4

24.7 ± 6.1

13.2 ± 3.2

67

0.3 mg/m3 CeO2

5.4 ± 1.9

33.5 ± 2.8

99.2 ± 10.1

85.1 ± 18.2

41.9 ± 8.8

69

1.0 mg/m3 CeO2

19.6 ± 5.6

152 ± 37.4

476 ± 74.0

366 ± 24.7

263 ± 15.4

108

3.0 mg/m3 CeO2

21.0 ± 1.0

391 ± 92.3

1280 ± 82.5

1285 ± 69.9

1013 ± 243

224

50.0 mg/m3 BaSO4

143 ± 16.3

1078 ± 197

1591 ± 530

871 ± 322

571 ± 358

56