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Table 3 Lung burden and clearance half-times of exposed rats

From: Effects from a 90-day inhalation toxicity study with cerium oxide and barium sulfate nanoparticles in rats

  Lung burden (μg/lung ± SD) Clearance t1/2 (days)
d 1 d 28 d 90 + 1rec d 90 + 28rec d 90 + 90rec
Clean air 1.2 ± 1.0 0.6 ± 0.2 1.8 ± 0.8 0.8 ± 0.5 1.3 ± 1.3 -
0.1 mg/m3 CeO2 2.5 ± 0.8 12.0 ± 2.9 33.1 ± 1.4 24.7 ± 6.1 13.2 ± 3.2 67
0.3 mg/m3 CeO2 5.4 ± 1.9 33.5 ± 2.8 99.2 ± 10.1 85.1 ± 18.2 41.9 ± 8.8 69
1.0 mg/m3 CeO2 19.6 ± 5.6 152 ± 37.4 476 ± 74.0 366 ± 24.7 263 ± 15.4 108
3.0 mg/m3 CeO2 21.0 ± 1.0 391 ± 92.3 1280 ± 82.5 1285 ± 69.9 1013 ± 243 224
50.0 mg/m3 BaSO4 143 ± 16.3 1078 ± 197 1591 ± 530 871 ± 322 571 ± 358 56