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Table 5 Detailed overview of histopathological findings with grade and incidence of effects per animal

From: Effects from a 90-day inhalation toxicity study with cerium oxide and barium sulfate nanoparticles in rats

Histopathological findings (♀)

Incidence

Lung

day 1

day 28

day 90 + 1rec

day 90 + 28rec

day 90 + 90rec

Ctrl.

CeO2

BaSO4

Ctrl.

CeO2

BaSO4

Ctrl.

CeO2

BaSO4

Ctrl.

CeO2

BaSO4

Ctrl.

CeO2

BaSO4

Accumulation, particle-laden macrophages, alveolar/interstitial

examined

10

10

10

10

10

10

10

10

10

10

10

10

10

10

10

very slight

0

10

10

0

10

10

0

10

10

0

1

5

0

1

9

slight

0

0

0

0

0

0

0

0

0

0

9

5

0

9

1

Accumulation, particle-laden macrophages, BALT

examined

10

10

10

10

10

10

10

10

10

10

10

10

10

10

10

very slight

0

5

5

0

10

8

0

6

8

0

5

6

0

6

3

slight

0

0

0

0

0

0

0

4

1

0

3

0

0

3

0

moderate

0

0

0

0

0

0

0

0

0

0

2

0

0

1

0

Hyperplasia, bronchiolo-alveolar

examined

10

10

10

10

10

10

10

10

10

10

10

10

10

10

10

very slight

0

0

0

0

4

1

0

4

2

0

7

1

0

5

1

slight

0

0

0

0

0

0

0

1

0

0

1

0

0

0

0

Infiltration of inflammatory cells, alveolar/interstitial

examined

10

10

10

10

10

10

10

10

10

10

10

10

10

10

10

very slight

0

0

0

0

2

0

0

6

5

0

5

5

0

5

3

slight

0

0

0

0

0

0

0

4

0

0

5

0

0

5

0

Particles, alveolar

examined

10

10

10

10

10

10

10

10

10

10

10

10

10

10

10

very slight

0

0

0

0

0

0

0

10

10

0

10

5

0

10

0

Giant cells, syncytial, BALT

examined

10

10

10

10

10

10

10

10

10

10

10

10

10

10

10

present, no grade

0

0

0

0

0

0

0

2

0

0

5

0

0

2

0

Fibrosis, interstitial

examined

10

10

10

10

10

10

10

10

10

10

10

10

10

10

10

very slight

0

0

0

0

0

0

0

2

1

0

3

1

0

7

0

Lung-associated lymph nodes

day 1

day 28

day 90 + 1rec

day 90 + 28rec

day 90 + 90rec

Ctrl.

CeO2

BaSO4

Ctrl.

CeO2

BaSO4

Ctrl.

CeO2

BaSO4

Ctrl.

CeO2

BaSO4

Ctrl.

CeO2

BaSO4

Accumulation, particle-laden macrophages, mediastinal lnn.

examined

10

10

10

10

10

10

10

10

10

10

10

10

10

10

10

very slight

0

0

0

0

7

10

0

2

7

0

0

6

0

0

5

slight

0

0

0

0

0

0

0

6

1

0

2

1

0

0

4

moderate

0

0

0

0

0

0

0

1

0

0

8

0

0

9

0

severe

0

0

0

0

0

0

0

0

0

0

0

0

0

1

0

Accumulation, particle-laden macrophages, tracheobronchial lnn.

examined

10

10

10

10

10

10

10

10

10

10

10

10

10

10

10

very slight

0

0

0

0

10

10

0

0

8

0

0

4

0

0

4

slight

0

0

0

0

0

0

0

3

2

0

0

5

0

0

6

moderate

0

0

0

0

0

0

0

6

0

0

8

1

0

10

0

severe

0

0

0

0

0

0

0

0

0

0

1

0

0

0

0

Giant cells, syncytial, mediastinal lnn.

examined

10

10

10

10

10

10

10

10

10

10

10

10

10

10

10

present, no grade

0

0

0

0

0

0

0

4

0

0

7

0

0

10

0

Giant cells, syncytial, tracheobronchial lnn.

examined

10

10

10

10

10

10

10

10

10

10

10

10

10

10

10

present, no grade

0

0

0

0

0

0

0

8

0

0

8

0

0

10

0

Nasal cavity

day 1

day 28

day 90 + 1rec

day 90 + 28rec

day 90 + 90rec

Ctrl.

CeO2

BaSO4

Ctrl.

CeO2

BaSO4

Ctrl.

CeO2

BaSO4

Ctrl.

CeO2

BaSO4

Ctrl.

CeO2

BaSO4

Accumulation of particle-laden macrophages, NALT

examined

10

10

10

10

10

10

10

10

10

10

10

10

10

10

10

very slight

0

0

0

0

5

8

0

10

4

0

6

0

0

10

0

Globules, eosinophilic, olfactory epithelial

examined

10

10

10

10

10

10

10

10

10

10

10

10

10

10

10

very slight

0

0

1

0

0

4

1

2

3

2

3

8

1

2

4

slight

0

0

0

0

0

0

0

0

6

0

1

1

0

0

3

Globules, eosinophilic, respiratory epithelial

examined

10

10

10

10

10

10

10

10

10

10

10

10

10

10

10

very slight

0

0

0

0

0

5

1

2

3

0

1

9

2

2

9

slight

0

0

0

0

0

0

0

0

6

0

0

0

0

0

1

Hyperplasia, mucous cell

examined

10

10

10

10

10

10

10

10

10

10

10

10

10

10

10

very slight

0

0

0

0

0

0

0

0

1

0

0

0

0

0

0

slight

0

0

0

0

0

0

0

0

4

0

0

1

0

0

1

Infiltration, inflammatory cell, subepithelial

examined

10

10

10

10

10

10

10

10

10

10

10

10

10

10

10

very slight

0

0

1

0

0

1

0

0

5

0

0

1

0

0

2

slight

0

0

0

0

0

0

0

0

0

0

1

1

0

0

0

  1. BALT bronchus-associated lymphoid tissue, NALT nasal mucosa-associated lymphoid tissue