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Table 5 Detailed overview of histopathological findings with grade and incidence of effects per animal

From: Effects from a 90-day inhalation toxicity study with cerium oxide and barium sulfate nanoparticles in rats

Histopathological findings (♀) Incidence
Lung day 1 day 28 day 90 + 1rec day 90 + 28rec day 90 + 90rec
Ctrl. CeO2 BaSO4 Ctrl. CeO2 BaSO4 Ctrl. CeO2 BaSO4 Ctrl. CeO2 BaSO4 Ctrl. CeO2 BaSO4
Accumulation, particle-laden macrophages, alveolar/interstitial examined 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
very slight 0 10 10 0 10 10 0 10 10 0 1 5 0 1 9
slight 0 0 0 0 0 0 0 0 0 0 9 5 0 9 1
Accumulation, particle-laden macrophages, BALT examined 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
very slight 0 5 5 0 10 8 0 6 8 0 5 6 0 6 3
slight 0 0 0 0 0 0 0 4 1 0 3 0 0 3 0
moderate 0 0 0 0 0 0 0 0 0 0 2 0 0 1 0
Hyperplasia, bronchiolo-alveolar examined 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
very slight 0 0 0 0 4 1 0 4 2 0 7 1 0 5 1
slight 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0
Infiltration of inflammatory cells, alveolar/interstitial examined 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
very slight 0 0 0 0 2 0 0 6 5 0 5 5 0 5 3
slight 0 0 0 0 0 0 0 4 0 0 5 0 0 5 0
Particles, alveolar examined 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
very slight 0 0 0 0 0 0 0 10 10 0 10 5 0 10 0
Giant cells, syncytial, BALT examined 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
present, no grade 0 0 0 0 0 0 0 2 0 0 5 0 0 2 0
Fibrosis, interstitial examined 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
very slight 0 0 0 0 0 0 0 2 1 0 3 1 0 7 0
Lung-associated lymph nodes day 1 day 28 day 90 + 1rec day 90 + 28rec day 90 + 90rec
Ctrl. CeO2 BaSO4 Ctrl. CeO2 BaSO4 Ctrl. CeO2 BaSO4 Ctrl. CeO2 BaSO4 Ctrl. CeO2 BaSO4
Accumulation, particle-laden macrophages, mediastinal lnn. examined 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
very slight 0 0 0 0 7 10 0 2 7 0 0 6 0 0 5
slight 0 0 0 0 0 0 0 6 1 0 2 1 0 0 4
moderate 0 0 0 0 0 0 0 1 0 0 8 0 0 9 0
severe 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Accumulation, particle-laden macrophages, tracheobronchial lnn. examined 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
very slight 0 0 0 0 10 10 0 0 8 0 0 4 0 0 4
slight 0 0 0 0 0 0 0 3 2 0 0 5 0 0 6
moderate 0 0 0 0 0 0 0 6 0 0 8 1 0 10 0
severe 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0
Giant cells, syncytial, mediastinal lnn. examined 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
present, no grade 0 0 0 0 0 0 0 4 0 0 7 0 0 10 0
Giant cells, syncytial, tracheobronchial lnn. examined 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
present, no grade 0 0 0 0 0 0 0 8 0 0 8 0 0 10 0
Nasal cavity day 1 day 28 day 90 + 1rec day 90 + 28rec day 90 + 90rec
Ctrl. CeO2 BaSO4 Ctrl. CeO2 BaSO4 Ctrl. CeO2 BaSO4 Ctrl. CeO2 BaSO4 Ctrl. CeO2 BaSO4
Accumulation of particle-laden macrophages, NALT examined 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
very slight 0 0 0 0 5 8 0 10 4 0 6 0 0 10 0
Globules, eosinophilic, olfactory epithelial examined 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
very slight 0 0 1 0 0 4 1 2 3 2 3 8 1 2 4
slight 0 0 0 0 0 0 0 0 6 0 1 1 0 0 3
Globules, eosinophilic, respiratory epithelial examined 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
very slight 0 0 0 0 0 5 1 2 3 0 1 9 2 2 9
slight 0 0 0 0 0 0 0 0 6 0 0 0 0 0 1
Hyperplasia, mucous cell examined 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
very slight 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0
slight 0 0 0 0 0 0 0 0 4 0 0 1 0 0 1
Infiltration, inflammatory cell, subepithelial examined 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
very slight 0 0 1 0 0 1 0 0 5 0 0 1 0 0 2
slight 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0
  1. BALT bronchus-associated lymphoid tissue, NALT nasal mucosa-associated lymphoid tissue