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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Multi-walled carbon nanotubes-induced alterations in microRNA let-7 and its targets activate a protection mechanism by conferring a developmental timing control

Fig. 5

Identification of downstream targets of HBL-1 in the regulation of MWCNTs toxicity. a Effect of hbl-1 mutation on the expressions of some potential target genes in MWCNTs exposed nematodes. b Effect of tir-1 or sym-1 mutation or RNAi knockdown of lpr-4 on MWCNTs toxicity in inducing intestinal ROS production. Sixty nematodes were examined per treatment. c Effect of tir-1 or sym-1 mutation on MWCNTs toxicity in decreasing locomotion behavior. Sixty nematodes were examined per treatment. Prolonged exposure was performed from L1-larvae to young adults. Exposure concentration of MWCNTs was 10 μg/L. Bars represent means ± SD. ** P < 0.01 vs wild-type (if not specially indicated)

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