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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Impact of copper oxide nanomaterials on differentiated and undifferentiated Caco-2 intestinal epithelial cells; assessment of cytotoxicity, barrier integrity, cytokine production and nanomaterial penetration

Fig. 6

Apparent permeability coefficient (Papp) of CuO NMs and CuSO4 across Caco-2 cells. Following differentiation Caco-2 cells were exposed to cell culture medium (control, 0), CuO NMs or CuSO4 at concentration of 3.17, 6.34 or 12.68 μg/cm2 Cu at the apical compartment for 24 and 48 h. The concentration of Cu in the apical and basolateral compartment were determined by ICP-OES. Papp was calculated using Eq. 2 (refer to Methods). Data are expressed in mean Papp ± SEM ×10−7 cm/s (n = 3). Significance p < 0.05 are indicted by * for comparison of treatment concentration or # for comparison of 24 and 48 h time point

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