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Table 2 Body and organ weights of the 5XFAD mice and their WT littermates after 3 or 13 weeks exposure to DEE of clean air

From: Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer’s disease

  3 weeks study 13 weeks study
Air DEE Air DEE
WT 5XFAD WT 5XFAD WT 5XFAD WT 5XFAD
Age (days) 101.6 ± 0.5 101.6 ± 0.5 101.5 ± 0.2 101.4 ± 0.1 171.0 ± 0.1 170.9 ± 0.2 170.6 ± 0.2 170.3 ± 0.1
Body weight, sacrifice (g) 23.5 ± 0.5 22.2 ± 0.4 21.9 ± 0.5 20.6 ± 0.3a 23.4 ± 0.7 23.6 ± 0.9 24.3 ± 0.7 23.6 ± 0.5
Body weight gain (g)c 3.9 ± 1.3 3.4 ± 1.0 2.6 ± 2.7 1.9 ± 0.8b 5.4 ± 0.6 4.7 ± 0.7 4.4 ± 0.3 4.9 ± 0.5
Liver/body weight (mg/g) 40.1 ± 3.37 45.69 ± 2.55 38.68 ± 1.66 43.24 ± 1.20 47.72 ± 4.40 43.13 ± 0.90 47.26 ± 1.99 44.20 ± 0.83
Lung/body weight (mg/g) 5.63 ± 0.14 5.64 ± 0.13 6.06 ± 0.52 5.86 ± 0.15 4.69 ± 1.04 6.48 ± 0.11 6.10 ± 023 6.09 ± 0.19
Heart/body weight (mg/g) 5.40 ± 0.24 5.28 ± 0.13 4.91 ± 0.21 5.35 ± 0.14 6.68 ± 0.36 5.81 ± 0.33 6.09 ± 0.24 6.11 ± 0.29
Kidney/body weight (mg/g) 11.31 ± 0.17 12.34 ± 0.29 12.39 ± 0.46 12.31 ± 0.19 10.98 ± 0.10 12.14 ± 0.33 12.33 ± 0.14 12.01 ± 0.30
Spleen/body weight (mg/g) 2.91 ± 0.13 2.85 ± 0.07 2.77 ± 0.09 3.01 ± 0.09 3.17 ± 0.22 3.74 ± 0.47 3.11 ± 0.09 3.26 ± 0.10
  1. Data represent mean ± standard error. Statistical analysis was performed using ANOVA with Tukey post hoc evaluation
  2. aversus clean air exposed WT mice (3 weeks), p < 0.01; bversus clean air exposed WT mice (3 weeks), p < 0.05
  3. cBody weight gain at time interval between exposure start and sacrifice