Table 2 Body and organ weights of the 5XFAD mice and their WT littermates after 3 or 13 weeks exposure to DEE of clean air
From: Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer’s disease
3 weeks study | 13 weeks study | |||||||
|---|---|---|---|---|---|---|---|---|
Air | DEE | Air | DEE | |||||
WT | 5XFAD | WT | 5XFAD | WT | 5XFAD | WT | 5XFAD | |
Age (days) | 101.6 ± 0.5 | 101.6 ± 0.5 | 101.5 ± 0.2 | 101.4 ± 0.1 | 171.0 ± 0.1 | 170.9 ± 0.2 | 170.6 ± 0.2 | 170.3 ± 0.1 |
Body weight, sacrifice (g) | 23.5 ± 0.5 | 22.2 ± 0.4 | 21.9 ± 0.5 | 20.6 ± 0.3a | 23.4 ± 0.7 | 23.6 ± 0.9 | 24.3 ± 0.7 | 23.6 ± 0.5 |
Body weight gain (g)c | 3.9 ± 1.3 | 3.4 ± 1.0 | 2.6 ± 2.7 | 1.9 ± 0.8b | 5.4 ± 0.6 | 4.7 ± 0.7 | 4.4 ± 0.3 | 4.9 ± 0.5 |
Liver/body weight (mg/g) | 40.1 ± 3.37 | 45.69 ± 2.55 | 38.68 ± 1.66 | 43.24 ± 1.20 | 47.72 ± 4.40 | 43.13 ± 0.90 | 47.26 ± 1.99 | 44.20 ± 0.83 |
Lung/body weight (mg/g) | 5.63 ± 0.14 | 5.64 ± 0.13 | 6.06 ± 0.52 | 5.86 ± 0.15 | 4.69 ± 1.04 | 6.48 ± 0.11 | 6.10 ± 023 | 6.09 ± 0.19 |
Heart/body weight (mg/g) | 5.40 ± 0.24 | 5.28 ± 0.13 | 4.91 ± 0.21 | 5.35 ± 0.14 | 6.68 ± 0.36 | 5.81 ± 0.33 | 6.09 ± 0.24 | 6.11 ± 0.29 |
Kidney/body weight (mg/g) | 11.31 ± 0.17 | 12.34 ± 0.29 | 12.39 ± 0.46 | 12.31 ± 0.19 | 10.98 ± 0.10 | 12.14 ± 0.33 | 12.33 ± 0.14 | 12.01 ± 0.30 |
Spleen/body weight (mg/g) | 2.91 ± 0.13 | 2.85 ± 0.07 | 2.77 ± 0.09 | 3.01 ± 0.09 | 3.17 ± 0.22 | 3.74 ± 0.47 | 3.11 ± 0.09 | 3.26 ± 0.10 |