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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Extracellular vesicle-packaged miRNA release after short-term exposure to particulate matter is associated with increased coagulation

Fig. 4

Influence of PM10 exposure on coagulation. a Investigation of whether the five validated miRNAs mediate the association between PM10 concentration (y-axis) and fibrinogen level (x-axis). β, coefficient of the independent variable when regressing the mediator on the independent variable; γ, coefficient of the mediator when regressing the dependent variable on both the independent variable and the mediator. An indirect effect (IE) represents the “mediated effect” through the five validated miRNAs. Estimates correspond to 10-μg/m3 increase in PM10 concentration. Results from regression models were adjusted for age, sex, BMI, smoking status, and apparent temperature. b Coagulation cascade. For each gene reported in the pathway, the possible regulatory role of each miRNA is reported

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