Fig. 1

In vitro IL-1β release and cytotoxicity in AM treated with silica ± imipramine. AM treatment conditions include IMP for 30 min, followed by exposure to LPS and silica for 24 h. a IL-1β release was measured by ELISA. b MTS assay results are expressed as cell viability relative to no silica, no IMP control. n ≥ 3 mice per treatment condition