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Fig. 8 | Particle and Fibre Toxicology

Fig. 8

From: Stat-6 signaling pathway and not Interleukin-1 mediates multi-walled carbon nanotube-induced lung fibrosis in mice: insights from an adverse outcome pathway framework

Fig. 8

PCR array identified the suppression of different fibrotic genes in IL-1R1 KO and STAT6 KO mice. A PCR array of fibrosis-associated genes was performed on RNA isolated from C57BL/6, IL-1R1 KO, and STAT6 KO mice 28 days after MWCNT challenge. Five genes were identified as significantly different between KO and WT mice exposed to MWCNTs in either STAT6 or IL-1R1 KO mice. Data represent mean ± SEM. n = 3. Statistical analysis was performed using t-tests. *p < 0.05

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