Table 2 Mutant frequency (MF) of gpt gene in the lungs of control and metal nanoparticle-exposed mice
From: Cobalt nanoparticles induce lung injury, DNA damage and mutations in mice
Treatment | Sex | No. of rescued colony | No. of mutant | MF (×10−6) | Average of MF ± SE (x10-6) |
|---|---|---|---|---|---|
Control | F | 477,000 | 5 | 10.5 | 11.6 ± 1.8 |
F | 540,000 | 9 | 16.7 | ||
M | 229,500 | 2 | 8.7 | ||
M | 1,429,500 | 15 | 10.5 | ||
Nano-Co | F | 397,500 | 20 | 50.3 | 55.2 ± 5.0* |
F | 684,750 | 27 | 39.4 | ||
F | 408,000 | 22 | 53.9 | ||
M | 415,500 | 20 | 48.1 | ||
M | 236,250 | 17 | 72.0 | ||
M | 311,000 | 21 | 67.5 | ||
Nano-TiO2 | F | 775,500 | 13 | 16.8 | 10.7 ± 1.9 |
F | 798,000 | 10 | 12.5 | ||
M | 1,117,500 | 7 | 6.3 | ||
M | 423,000 | 3 | 7.1 | ||
M | 451,500 | 5 | 11.1 |